As a control, treatment with the proteasome inhibitor MG132 caused an increase in AR levels even in the absence of PIAS1 (Figure 3f), proving that the proteasome accounts for the observed effect. These results clearly demonstrate that PIAS1 delays the proteasomal degradation of AR and is ...
30mCON, and 30mRM mice, as well as 9-month-old control (9mCON) and 9-month-old TSCmKO (9mTSCmKO) mice with or without a 4-week treatment of rapamycin (2 mg kg−1 day−1, i.p). Age- and mTORC1-induced changes were examined ...
The hydronium ion concentration of an aqueous solution of 0.525 M phenol (a weak acid), C6H5OH, (Ka = 1.00 x10-10) is [H3O+] = M. Caffeine (C8H10N4O2) is a weak base with a pKb of 10.4. Calculate the pH of a solution con...
In Cohort-1, there were no dose limiting toxicities and the highest dose group (120mg/m2) tolerated PIPAC well. Three patients underwent a second PIPAC. One patient had marked improvement in PCI from 30 to 12, while the remaining two patients had stable PCI/peritoneal regression grading (...
Gerbera hybrida is one of the most popular cut flowers in the world; however, stem bending, which always happens when gerbera flower harvested from the field, greatly limits its vase life. To date the molecular mechanisms underlying stem bending remain p
Among these specimens, 44 (36.7%) tissues displayed weak staining and 40 (33.3%) showed strong staining. Furthermore, elevated expression of METTL3 was significantly associated with pN stage (p = 0.003), pM stage (p = 0.001), TNM stage (p < 0.001) and vessel invasion (p...
The TUBB3 and ERCC1 staining intensities (cytoplasmic staining for TUBB3 and nuclear staining for ERCC1) were graded on a scale of 0 to 2 (0 = none, 1 = weak, and 2 = strong), using adjacent non-malignant cells for reference. The percentage of positive tumor cells was ...
However, the CDS1 immunoreactivity was traced to a peripheral p55 cross-reactive mitochondrial protein and the mitochondrial CDS activity was due to a peripheral mitochondrial protein, TAMM41, not an integral membrane protein as expected for CDS1. TAMM41 is the mammalian equivalent of the recently ...
concentration of 0.8 mg/ml in 500 ml. To this volume, 20 mg The protein expression of each GABAAR subunit was of biotinylated lectin, including Concanavalin A (ConA; determined by measuring the integrated intensity of Vector Labs, Burlingame, CA), lycopersicon esulentum each subunit and ...
Indeed, a weak BS activity (<0.3 pKat mg protein−1) was detected in crude extracts of N. benthamiana leaves. Despite the low benzaldehyde levels detected, tobacco leaves with the introduced whole pathway produced 321.5 nmol g FW−1 more benzylalcohol than the leaves expressing ...