What is non-melanoma skin cancer? How common is melanoma? How dangerous is squamous cell skin cancer? How long does a melanoma take to develop? Is carcinoma worse than melanoma? Is melanoma a carcinoma or sarcoma? How does skin cancer affect the body?
Subungual malignant melanoma: a clinical-pathologic study Female patients have a relatively good prognosis as opposed to the poor prognosis of male patients. Paradoxically, a few patients with relatively shallow ... RH Patterson,EB Helwig - 《Cancer》 被引量: 0发表: 2019年 Local Control of Breas...
Melanoma antigen gene (MAGE)-A6 and MAGE-A11 are two of the most cancer-testis antigens overexpressed in various types of cancers. However, the clinical and prognosis value of MAGE-A6 and MAGE-A11 co-expression in the pathophysiology of the bladder is unknown. Three studies were selected from...
Interestingly, the observed relationship of the stem cell phenotype of Merkel cell carcinoma with a more aggressive clinical course is similar to that reported in other lineage-unrelated skin entities. In fact, progression to malignant melanoma has been shown to be associated with expression of stem...
the placenta usually prevents cancer cells from reaching the fetus. About 1 in 1,000 pregnant people are thought to have cancer. The chance of cancer being transmitted is estimated at only 0.000005%. When it does happen, cancer transmission is most common with leukemia/lymphomas and melanoma.9...
To study the functional role of HPK1 in cancer, we took advantage of a transplantable mouse melanoma model, B16-F10. We found that the growth rates of B16-F10 tumors were significantly decreased in MAP4K1−/−mice compared with wild-type (WT) controls (Figure 1E). Next, to test ...
(P27/KIP1) have been reviewed7,39. While miR-595 has no established role in breast cancer, it has tumor promoter roles in papillary thyroid carcinoma (PTC)40and human glioblastoma (GBM) cells41. However, miR-595 acts as a tumor suppressor in ovarian cancer42; thus, its role in breast...
To inhibit a downstream target such as MEK, which plays an important role in many steps of tumorigenesis, could also be a significant opportunity. The MEK inhibitor trametinib is already used in the treatment of metastatic melanoma harboring the BRAF mutation and as a part of a drug combination...
cancer-associated fibroblasts; pancreatic ductal cell carcinoma; ELI; PDAC; fibroblast; stromal invasibility; cancer stroma; cancer dissemination; initiation of metastasis; cancer stroma interaction1. Introduction The understanding of cancer metastasis as a cell autonomous disease of tumor cells has ...
(including melanoma, Merkel cell carcinoma, Hodgkin's lymphoma, and MSI high malignancies) ranges from 40 to 70% in unselected patients [107]. Unfortunately, the majority of other recognized advanced cancers such as advanced non-small-cell lung cancer, advanced or metastatic urothelial cancer (mUC...