(1973). Is malignant melanoma an endocrine-dependent tumor? The possible adverse effect of estrogen. Oncology, 27, 244.Sadoff, L., Winkley, J., Tyson, S. (1973) Is malignant melanoma an endocrine-dependent tumor?. Oncology 27: pp. 244-257...
While melanomas commonly harbor losses of 9p21, on which CDKN2A resides, the presence of additional tumor suppressor elements at this locus is incompletely characterized. Here we assess the expression levels and functional role of microRNA-876-3p (miR-87
A malignant tumor is a cancerous tumor capable of metastasis, or the ability to spread to healthy tissues in other parts of the body. Learn how to define a malignant tumor, then explore its possible treatments, such as surgery, chemotherapy, and radiation therapy. ...
Here, we report the definition of miR-339-3p as a novel tumor suppressive microRNA that blocks melanoma cell invasion without affecting cell survival. miR-339-3p was identified by a comprehensive functional screen of a human miRNA mimetic library in a cell-based assay for invasion by the ...
One identified cDNA encoded TROY, a member of the tumor necrosis factor receptor superfamily (TNFRSF). TROY is widely expressed during embryogenesis, but in adults expression is restricted to hair follicles and brain. However, TROY had never been associated with melanoma, and it was selected for...
Loss of Spry1 reduces the growth of BRAFV600-mutant cutaneous melanoma and improves response to targeted therapy. Cell Death Dis. 2020;11:392. Article CAS PubMed PubMed Central Google Scholar Wang Y-Y, Wang W-C, Su C-W, Hsu CW, Yuan SS, Chen YK. Overexpression of Sprouty1 protein ...
Dysregulation of Cav1 expression in the human skin is associated with hyperproliferative diseases such as melanoma and non-melanoma cancers as well as psoriasis67,68. In melanoma, Cav1 function remains very controversial, since it is recognized as a tumor suppressor and an oncogene69. Such discrep...
We now show that fibronectin is a target gene of B-Raf signaling in melanoma cell lines but not in normal melanocytes, and that tumor-derived fibronectin may contribute to melanoma tumorigenesis by promoting invasion of cells that contain the B-Raf V600E mutation....
Tumor family history 0.647 (0.354) A Cox proportional hazards model was established to verify the independent effect of IRGM on human melanoma. IRGM (transcript and expression) is presented as a dominant factor; alcohol use, smoking, and tumor family history are presented as cooperative factors....
Signal Transduction and Targeted Therapy (2024) Translational control by VARS in melanoma Qiushuang Wu Sohail F. Tavazoie Nature Cell Biology (2024) Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma Najla El-Hachem Marine Leclercq Pierre Close Nature Cell Biology (2024)Assoc...