The critical factors are the acid/base status and the lipophilicity of the molecule. In all cases, there are no direct consequences of drug-melanin binding. Drug-related toxic effects on the retina described in humans and animals are unrelated to melanin binding: melanin binding and retinal ...
His darker pigmentation is the result of the presence of high levels of melanin, a molecule that protects his skin against the ultraviolet rays of the sun. Without melanin acting as a shield from the sun, the Ibo man would burn or contract skin cancer. [ILLUSTRATION OMITTED] The ...
Pigmentation is caused by the distribution of melanin, a black or brown pigment molecule, under your skin. This pigment exists to protect your skin cells from the sun, and everybody has it. But normally, we don’t notice a nice, even distribution of melanin. We just like how it looks—...
Aspergillus niger as a cell factory for the production of pyomelanin, a molecule with UV-C radiation shielding activity Melanins are complex pigments with various biological functions and potential applications in space exploration and biomedicine due to their radioprotectiv... SM Koch,C Freidank-Po...
A thin scaling indicates disease activity (Fig. 1). The “evoked-scale” sign (Zireli’s sign) corresponds to the scaling observed when the skin is stretched (Hudson et al., 2018). Some fungal metabolites have been linked to the clinical presentation of p. versicolor such as melanin, ...
Melanin is a group of natural pigments that give hair and skin their varied colors. With aging, melanin disappears from hair fibers, leading to color loss and graying. Most permanent hair dyes use ammonia, hydrogen peroxide, small-molecule dyes and other ingredients to penetrate the cuticle of ...
of the mitf gene, which is the master regulator of melanophore–melanocyte differentiation in teleosts62, and is also responsible for colouration in rock pigeons63, mchr1, a melanin-concentrating hormone receptor, and a TRYP, located in melanocytes and involved in the production of melanin64. We...
Marı´a del Carmen Arias EsparzaElsevier BVMitochondrionSolis-Herrera, A.; Arias-Esparza, M.d.C. The unexpected capacity of melanin to dissociate water molecule is a new way to improve mitochondrial cytopathies. Mitochondrion, 2010, 10, 200-201....
as depicted in Fig.5. The polypeptide chain deformability plot showed alterations in all the residues depicted by the tips of the peaks known as hinges where CaCYP51 and BagA interacted. Main-chain deformability refers to a molecule’s ability to shapeshift every amino acid residue in a polypep...
The therapeutic options for Alzheimer’s disease (AD) are limited, underscoring the critical need for finding an effective regulator of Aβ42 production. In this study, with 489 human postmortem brains, we revealed that homotrimer G protein subunit gamma 5 (GNG5) expression is upregulated in ...