In filamentous fungi, the cAMP/PKA pathway has also been shown to mediate the response to glucose sensing13,16,17. In the presence of glucose, PKA is important for spore germination, hyphal growth, cell wall homeostasis and secondary metabolite production whilst inhibiting alternative carbon source...
Financial performance, company reputation, and investor relations partially mediate the relationship between a company’s ESG practices and executive compensation. Specifically, financial performance acts as a negative mediator, while company reputation and investor relations serve as positive mediators. ...
a claimant may then immediately perform the attached condition (such as delivering another token on some destination chain) and then claim the allocated tokens by initiating a call to the associated arbiter, which will verify and mediate the terms and conditions of the associated compact and relay...
Hedgehog-activated Fat4 and PCP pathways mediate mesenchymal cell clustering and villus formation in Gut Development. Dev Cell. 2020;52(5):647–e658646. Article CAS PubMed Google Scholar Wang P, Wang Y, Fan X, Liu Y, Fan Y, Liu T, Chen C, Zhang S, Chen X. Identification of ...
Obesity is a worldwide epidemic characterized by adipose tissue (AT) inflammation. AT is also a source of extracellular vesicles (EVs) that have recently been implicated in disorders related to metabolic syndrome. However, our understanding of mechanisti
Exercise-induced upregulation of proteasome activity [39] may also mediate the degradation of proteolytic fragments of APP [40, 41]. In addition, cholinergic activity increases with exercise, and regulation of the cholinergic system has been implicated in exercise-induced plasticity [36]. Taken ...
Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis. Nat Cell Biol. 2018;20:1290–302. Article CAS PubMed Google Scholar Hamidi H, Ivaska J. Every step of the way: integrins in cancer progression and metastasis. Nat Rev Cancer. 2018;18:...
In contrast, an ESB involves using a central bus or message broker to mediate the communication between applications and services, and to provide a unified interface for accessing them. Here are some key differences between point-to-point integration and ESB: Complexity and scalability: Point-to-...
APOE4 may also mediate disease through altered inflammatory states and vascular dysfunction72. Damaged cerebral vasculature or increased presence of inflammatory mediators may disproportionately affect the isodendritic core, given the greater metabolic demands of the long and highly arborized neurons5,6,7...
The capacity to learn enabled the human species to adapt to various challenging environmental conditions and pass important achievements on to the next generation. A growing body of research suggests links between neocortical folding properties and numer