This year, more than 1 million Americans and more than 10 million people worldwide are expected to be diagnosed with cancer, a disease commonly believed to be preventable. Only 5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots i...
Cancer—always believed to be caused by genetic cell mutations—can in reality be caused by infections from viruses, bacteria, and fungi.“I believe that, conservatively, 15 to 20% of all cancer is caused by infections; however, the number could be larger—maybe double,”said Dr. Andrew Dan...
2012. IDO is a nodal pathogenic driver of lung cancer and metastasis development. Cancer Discov. 2:722.Smith C, Chang MY, Parker KH, Beury DW, DuHadaway JB, Flick HE et al. IDO is a nodal pathogenic driver of lung cancer and metastasis development. Cancer Discov 2012; 2: 722-735....
Despite relevant progresses in personalized approach to lung cancer, many aspects remain to be clarified. One of the most important issue is that lung cancers have different pathologic features. In this perspective non-solid malignant lung nodules define a still obscure neoplastic entity. Although many...
We performed prognostic analyses of the patients with primary lung cancer initially completely resected. Twenty-four patients who had undergone incomplete resection or surgical biopsy for diagnosis and 40 patients with stage-IIIB or -IV disease were excluded. Forty additional cases were excluded due to...
High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of... Allele loss involving chromosome arm 3p is one of the most frequent and earliest known genetic events in lung cancer pathogenesis and may affect...
Inhibition of CXCR5 function, by trapping CXCR5 in the endoplasmic reticulum using a CXCL13-KDEL "intrakine," had no effect on initial growth of liver foci but later caused a prolonged growth arrest. In contrast, s.c. and lung tumors of CXCR5- and intrakine-transfected cells grew at ...
R. et al. Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke’s disease. Science 322, 1395–1399 (2008). Article ADS CAS PubMed PubMed Central Google Scholar Kelleher, F. C., Rao, A. & Maguire, A. Circadian molecular clocks and cancer. Cancer Lett....
Beneficial treatment of patients with advanced cancer using a Newcastle disease virus vaccine (MTH-68/H). Newcastle Disease Virus Vaccine (MTH-68/H) was administered to patients suffering from advanced neoplastic diseases after non-efficient tumor-destructive t... LK Csatary,RW Moss,J Beuth,......
Patients had been followed-up for lung cancer (n=10), lymphoma (n=9), breast cancer (n=7), urologic cancer (n=6), gastro-intestinal tumors (n=6), larynx/pharynx tumors (n=4), gynaecologic tumors (n=3), other cancer (n=8). 6 patients had a history of two tumors or more in...