Furthermore, the inhibitory function of NGP against the inflammatory effect of LPS could be observed in both in vitro and in vivo. With these findings, we report NGP is a novel secretory protein to mask LPS and inhibit its function.Jaewoo Hong...
Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. J Exp Med. 1994; 180 :1025–... Wurfel,M M. - 《Journal of Experimental Medicine》 被引量: 760发表: 1994年 Macrophage colony-stimulating factor gene expression in vascular...
Lipopolysaccharide binding protein (LBP) is an acute-phase reactant that binds bacterial LPS. We show that LBP binds to the surface of live Salmonella and ... Wright,S.,D. - 《Journal of Experimental Medicine》 被引量: 1088发表: 1989年 Micellar complexes of human apolipoprotein A-I with ...
we performed a direct comparison of the effect of classical pro-inflammatory stimuli on human and mouse myeloid cells in vitro. We examined the effect of LPS (10 ng/mL and 100 ng/mL), IFNγ and IFNα (1 ng/mL and 10 ng/mL) at 4, 8 and 24 h on primary human monocyte...
LPS is a strong inducer of inflammation and an efficient tool to study effects of neuroinflammation on Aβ-burden in amyloid-β precursor protein (AβPP)-transgenic mice. However, the findings are not consistent with reported effects of both increased28,29,30,31 and decreased32,33,34,35,36...
This was not the case when phorbol myristate acetate (PMA) was used as a second triggering agent, suggesting that the monocyte hyporesponsiveness due to LPS does not affect all activation pathways, particularly that of protein kinase C. On the other hand, both PMA and zymosan pretreatment could...
It appears that this catalytically different TACE protease activity might have a significant contribution to TNF-α release in LPS activated THP-1 cells, by contrast to human monocytes where the TACE activity remains catalytically unchanged even after LPS activation. Conclusions/Significance: On the ...
An age-dependent increase in major histocompatibility complex (MHC) class II mRNA and protein expression was detected in microglia. Moreover, peripheral LPS injection caused a more pronounced increase in IL-1β, IL-10, Toll-like receptor (TLR)-2, and indoleamine 2,3-dioxygenase (IDO) mRNA ...
HPTTMLipopolysaccharide (LPS) serotype O113, Highly Purified Toxin, is produced by methods ensuring the greater purity of the product. This process uses a hot phenol extraction and proprietary chromatographic methods that effectively remove traces of protein and nucleic acid while maintaining consistently...
ISG15 is an interferon-stimulated, ubiquitin-like protein that can conjugate to substrate proteins (ISGylation) to counteract microbial infection, but the underlying mechanisms remain elusive. Here, we use a virus-like particle trapping technology to ide