5). How anesthetics such as isoflurane, which potentiates inhibition45, lead to this profound change of dynamics remains a challenge for neural network modeling. The fact that, unlike the cortex, the thalamus generates different assemblies for ongoing and evoked activity under anesthesia indicates ...
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Remarkably, loss of tau does not lead to a major phenotypic change after chronic or acute knockout in cells or animals [2, 3]. This proves that—contrary to popular belief—tau’s primary role is not to stabilize microtubules in vivo. In turn this suggests that tau contributes to ...
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As cloud usage expands and the pace of application deployments and updates accelerates, many security teams are increasing their focus on application segmentation. There are multiple approaches to application segmentation, which can lead to confusion as security teams compare traditional application segmentat...
During the first phase, post-transcriptional regulation of maternal transcripts and post-translational regulation of maternal proteins predominate. The former is coordinated by RNA-binding proteins (RBPs), which regulate the translation, stability, and localization of the maternal transcripts. A large ...
We show further that estimates made from changes in transcript levels may lead to incorrect predictions regarding the abundance of the cognate proteins. Concordance between mRNA and protein expression has often been used to estimate the contribution of transcriptional regulation on changes in protein ...
The exception to this “either power lead” rule is three-phase power where one of the same part numbers is installed in series in each of the three power leads. The Future of Inrush Current Limiters Although inrush current limiters have been widely used for tens of years, the swi...
Deliberate misclassification may lead to unintended financial consequences and shipping delays. Carrier Relationships: Familiarize yourself with the protocols and guidelines of the carrier you choose. Building a strong relationship with your carrier contributes to a smoother shipping experience. Traversing the...
Metabolite extraction constrains the analytical scope of metabolomics experiments, and efforts to optimize extraction conditions may lead to approaches that enhance metabolome coverage. To this end, we sought to improve polar metabolite coverage through post-homogenization water addition using cryopulverized ...