Mammalian lactate dehydrogenase D (LDHD) catalyzes the oxidation of D-lactate to pyruvate. LDHD mutations identified in patients with D-lactic acidosis lead to deficient LDHD activity. Here, we perform a systematic biochemical study of mouse LDHD (mLDHD) and determine the crystal structures of mLD...
Background A well-known characteristic of tumor cells is the propensity to produce lactic acid under normoxia and hyperoxia, also referred to as the Warburg effect. High levels of lactic acid are believed to be associated with elevated expression of lactate dehydrogenase A (LDHA), a gene up...
The Bifidobacterium species holds much promise for providing benefits to the host. These include the protection of neonatal animals from pathogenic viruses, bacteria and fungi, production of promoting factors for the host, providing adjuvant activity for antigens of pathogenic bacteria [35]. Bifidobacter...
Sperm motility decreased in response to exposure to L-lactic acid in a dose-dependent manner, while D-lactic acid had a lesser inhibitory effect (Fig. 4a and Supplementary Movie 3), suggesting the involvement to some extent of molecules with stereospecificity such as lactate/ pyruvate ...
The results of proteomic analyses suggested the presence of certain proteins in the active fractions, such as arginine deiminase or glucose-degrading enzymes, including lactate dehydrogenase. These enzymes have the ability to metabolize nutrients leading to cancer cell starvation. We hypothesized this ...
Mutations such as that leading to the αV138M variant in pyruvate dehydrogenase, the pyruvate-decarboxylating PDHc E1 component, can result in PDHc deficiency, an inborn error of metabolism that results in an array of symptoms such as lactic acidosis, progressive cognitive and neuromuscular deficits...
You can definelactic acid fermentationas the process that occurs after glycolysis in anaerobic respiration. An enzyme called lactate dehydrogenase prompts a reaction to start glycolysis, forming lactate in the process. This lactate protonates into lactic acid and continues accumulating in muscle cells un...
The recovery of stable caproate manufacturing (68.9 ± 2.2 mmol C/L/d), complete lactate consumption, and large hydrogen co-production (748 ± 76 mLH2/d) ended up being observed as an impact associated with inclusion of an external acetate. The lactate transformation Secondary autoimmune ...
Supplementary Data 1also provides a list of the reactions in theE. colimodel sorted with respect to the frequency of their occurrence in the found cMCS. As can be expected, reactions lying on pathways to standard (fermentation) products ofE. coli(for example, lactate dehydrogenase, acetate kinas...
the terms “lactic acid”, “glucose”, “xylose” and “galactose” all include their D-form and L-form isomers. Furthermore, when a saccharide can present in both open ring form and ring form at the same time, the chair form of its conformation isomer and its α, β isomers are all...