Silk cocoon of Bombyx mori: proteins and posttranslational modifications--heavy phosphorylation and evidence for lysine-mediated cross links. Although silk is used to produce textiles and serves as a valuable biomaterial in medicine, information on silk proteins of the cocoon is limited. Scanning......
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Mutations in enzymes that modify histone H3 at lysine 4 (H3K4) or lysine 36 (H3K36) have been linked to human disease, yet the role of these residues in mammals is unclear. We mutated K4 or K36 to alanine in the histone variant H3.3 and showed that the K4A mutation in mouse embryon...
Histone acetylation is a predominant active chromatin mark deposited by histone acetyltransferases (HATs) that transfer the acetyl group from acetyl coenzyme A (acetyl-CoA) to lysine ε-amino groups in histones. GENERAL CONTROL NON-REPRESSED PROTEIN 5 (GCN5) is one of the best-characterized HATs ...
The homologous regions include the conserved catalytic residues of iPLA2, including the GDSRG sequence, in which the arginine is replaced by a lysine in VipD. VipD has phospholipase A activity with diacyl glycerophospholipid substrates [34]; plasmalogen was not tested as a substrate. If the ...
The combination of enrichment techniques for post-translationally modified peptides and mass-spectrometric approaches for the identification of PTMs has been responsible for the discovery of many diverse protein modifications (3). Among these, acylation at lysine residues is one of the most prevalent ...
The spermine block of Cx40 gap junctions was subsequently demonstrated to be dependent on the presence of two glutamic acid residues located at positions 9 and 13 on the cytoplasmic amino-terminal (NT) domain of Cx40 (Musa et al. 2004). However, replacement of the naturally occurring lysine ...
yoelii were washed in PBS, allowed to adhere on to poly(l-lysine)-coated glass cov- erslips and subsequently fixed in 2.5% glutaraldehyde in 0.1 M cacodylate buffer (pH 7.2). After fixation, samples were rinsed in 0.1 M cacodylate buffer for 30 min at 4 °C. They were then post- ...
1a)5,6. Similarly, in the biosynthesis of s56-p1, lysine is oxided to N6-hydroxylysine, and the N6-hydroxyl is then joined with the carboxyl group of glycine. The N–N bond is subsequently formed through intramolecular nucleophilic attack by the glycine amino group (Supplementary Fig. 1b)...