However, certain kinds of dermatophytosis, including widespread infections and those of hair and nails, will often respond poorly to topical therapy and will require prolonged courses of an oral antifungal agent, such as griseofulvin, ketoconazole, itraconazole, fluconazole, and terbinafine. There is...
at high doses it can causebone marrow suppressionandpanleukopenia.9Also, griseofulvin is teratogenic and cannot be given to pregnant does. Owners administering griseofulvin should wear gloves. Ketoconazole (Nizoral, Janssen Pharmaceuticals, Titusville, NJ) (10-15 mg/kg PO q24h) can be administered ...
Strong CYP3A4 inhibitordrugssuch asketoconazoleor high-doseritonavir, because these can increase the concentration of isavuconazole and the risk for toxicity and adverse effects. Strong CYP3A4 inducer drugs rifampin,carbamazepine, St. John’s wort, or long-actingbarbiturates, because these can signifi...
Clinical experience supports the use of itraconazole and ketoconazole (400 mg/day), for 18–24 months.210–212 Fluconazole has proved less successful. The newer triazoles are efficacious but cost-prohibitive in resource-limited settings. Posaconazole (80% success) is dosed at 400 mg every 12 h ...