To prevent spread, anyone in close contact with a symptomatic patient should be treated with ketoconazole 2% shampoo. Fomites such as combs, hats, and hair accessories should also be disinfected or discarded. Some also advocate for the evaluation of home pets, who often serve as a persistent so...
Tinea unguium is usually caused by one of two fungi:Trichophyton rubrumorT. interdigitale. Although Tinea unguium can refer to fungal infection of the fingernails or toenails, toenails are much more likely to contract this disease. Those especially prone to nail fungus include men, older adults, ...
However, certain kinds of dermatophytosis, including widespread infections and those of hair and nails, will often respond poorly to topical therapy and will require prolonged courses of an oral antifungal agent, such as griseofulvin, ketoconazole, itraconazole, fluconazole, and terbinafine. There is...
Strong CYP3A4 inhibitordrugssuch asketoconazoleor high-doseritonavir, because these can increase the concentration of isavuconazole and the risk for toxicity and adverse effects. Strong CYP3A4 inducer drugs rifampin,carbamazepine, St. John’s wort, or long-actingbarbiturates, because these can signifi...
Clinical experience supports the use of itraconazole and ketoconazole (400 mg/day), for 18–24 months.210–212 Fluconazole has proved less successful. The newer triazoles are efficacious but cost-prohibitive in resource-limited settings. Posaconazole (80% success) is dosed at 400 mg every 12 h ...
fortopical applicationororal administration. However, certain kinds of dermatophytosis, including widespread infections and those of hair and nails, will often respond poorly to topical therapy and will require prolonged courses of an oral antifungal agent, such asgriseofulvin, ketoconazole,itraconazole,...