mRNA gene expression analyses were performed within R2: a genomics analysis and visualization platform (http://r2.amc.nl), using datasets: NB Kocak (n = 649, GEO:GSE45547, patient cohort 1), NB Versteeg (n = 88, GEO:GSE1647688/122, patient cohort 2), and NB Research Consortiu...
Amynthas corticis(Kinberg, 1867), is in the Megascolecidae, which has a primarily Asian-Australasian distribution. With physical dispersal,A. corticishas become a cosmopolitan invasive species with an east Asian origin. It has been suggested that the invasive ability ofA. corticisis due to it...
Under a Creative Commons license open accessNicotinic acid adenine dinucleotide phosphate (NAADP) is a molecule capable of initiating the release of intracellular Ca2+ required for many essential cellular processes. Recent evidence links two-pore channels (TPCs) with NAADP-induced release of Ca2+ from...
Transfection of MPM cells with a miR-17-5p mimic or KCNMA1-specific siRNAs reduced mRNA expression of KCa1.1 and inhibited MPM cell migration. Similarly, treatment with paxilline, a small molecule inhibitor of KCa1.1, resulted in suppression of MPM cell migration. Conclusion These functional data...
(c) the chiral centre that allows the proper spatial disposition of the molecule; (d) an additional phenoxy group that remarkably stabilises the binding ... - 《Br J Pharmacol》 被引量: 19发表: 2003年 An in situ XRD investigation of singly and doubly promoted manganese oxide methane coupling...
Loss of this single molecule resulted in cell death, despite or perhaps attributable to the presence of other oncogenic events. This suggests a generalizable model in which aberrations inherent to cancer generate tonic death signals that would otherwise kill the cell if not opposed by a requisite ...
we measured Ca2+entry in fura-2-loaded cells in response to a 1-min depolarization with 90 mM KCl. This experiment revealed increased Ca2+entry in response to depolarization with KCl in STIM1-KO cells compared to wild-type cells (Fig.8a). In order to evaluate the contribution of dihydropyr...
In some experiments, at 6 hours after infection, the cultures were treated with a C1 compound [N'-(3,5-dibromo-2-hydroxybenzylidene)-4-nitrobenzohydrazide, cat#5113023, ChemBridge, San Diego, CA], a small molecule known to inhibit Yersinia type III secretion system (T3SS) and block ...
Many studies from independent laboratories have implicated erythrocyte NO generation and/or delivery as a critical source of hypoxic vasodilation, although questions remain about the nature and stability of the molecule carrying “NO bioactivity”5,6,7,8. Other sources of NO for hypoxia-driven ...
Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD). Conditions of stress or injury induce APOE expression within neurons, but the role of neuronal APOE4 in AD pathogenesis is still unclear. Here