The open ScPDR5 structure with bound rhodamine 6G substrate was used as the target (PDB ID: 7p05). The US simulations were performed with the Amber20 package, using the RMSD to backbone atoms of the transmembrane helices of the target as the collective variable (Supplementary Fig. 1). ...
So far, due to its clinical importance—as connected to the multidrug resistance—a non-selective transporter HsABCG2 is one of the most studied proteins from the G subfamily. Obtained HsABCG2 cryo-EM data provide some structure–function insights. For instance, it enabled for the identificatio...
If you occasionally use FTP to transfer a few small files, Windows Explorer might get the job done. But its fixed 4 KB buffer size makes it a poor choice for anything beyond casual use. Tools like FileZilla, with its 256 KB buffer, or WinSCP, with configurable options, offer a much be...
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induced portfolio signalling effect and the re-anchoring channels. Increasing the holdings of government bonds on the SARB balance sheet is consistent with its primary mandate of price stability and macro-financial stability. The size of the SARB balance sheet is another major monetary policy tool ...