The open ScPDR5 structure with bound rhodamine 6G substrate was used as the target (PDB ID: 7p05). The US simulations were performed with the Amber20 package, using the RMSD to backbone atoms of the transmembran
A very important open question in stem cells regulation is how the fine balance between GSCs self-renewal and differentiation is orchestrated at the molecular level. In the past several years much progress has been made in understanding the molecular mec
So far, due to its clinical importance—as connected to the multidrug resistance—a non-selective transporter HsABCG2 is one of the most studied proteins from the G subfamily. Obtained HsABCG2 cryo-EM data provide some structure–function insights. For instance, it enabled for the identificatio...
If you occasionally use FTP to transfer a few small files, Windows Explorer might get the job done. But its fixed 4 KB buffer size makes it a poor choice for anything beyond casual use. Tools like FileZilla, with its 256 KB buffer, or WinSCP, with configurable options, offer a much be...
This is because a very short window implies that there are risks of missing the full market reaction, as it may take time for the market to evaluate the news. On the other hand, if a very long window is chosen, the risks are that the estimated reaction can be contaminated by other ...