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This evolution takes place faster than your facilities do. You've probably already experienced that the ‘c' in the cGMP status needs to be brought back into your facility, processes, or procedures and it appears to be a big hurdle to overcome. The FDA publishes systems for current good man...
CGMP:Cisco Group Management Protocol(思科组管理协议) CHAP:Challenge Handshake Authentication Protocol(PPP挑战握手认证协议) CIF:Cells in Frames(帧中信元技术) CIFS:Common Internet File System(通用Internet文件系统) CLDAP:Connectionless Lightweighted Directory Access Protocol(单机轻量级目录访问协议) CLNP:Connecti...
cause i know where iv cause i like to be go cause i liked it cause i love you cause i never want to cause i really need t cause i saw the end b cause i ve heard cause im not the one cause im not your pri cause ive bee sing yo cause ive been waitin cause ive got a thing...
cGMP depletes intracellular calcium and further induces smooth muscle relaxation with resultant penile vasodilation (Burnett, 1995b; Ignarro et al., 1990; Lugg et al., 1995a; Moncada, 1992). Other chemical entities have been implicated in the control of erection, including prostaglandins E1 (...
The cGMP phosphodiesterase (PDE) of cattle retinal rod outer segments comprises three types of sub-units: the two heavy catalytic ones, PDEα and PDEβ , each around 85 kDa, and the light inhibitory one, PDEγ or I (11 kDa). The relative stoichiometry is usually assumed to be 1:1:1....
Platelet activation is strongly affected by nitric oxide/cyclic GMP (NO/cGMP) signaling involving cGMP-dependent protein kinase I (cGKI). Previously it was shown that interaction of the cGKI substrate IRAG with InsP(3)RI is essential for NO/cguanosine monophosphate (GMP)-dependent inhibition of ...
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Some evidence has recently been provided for a possible role of cyclic guanosine monophosphate (cGMP) as a neuronal second messenger in the superior cervical ganglion, the retina and the cortex (9, 18, 20, 22, 26). In the superior cervic... CD Woody - Springer US 被引量: 6发表: 1978...
It is shown that ectopic expression of MRP8 reduces basal intracellular levels of cAMP and cGMP and enhances cellular extrusion of cyclic nucleotides in the presence or absence of stimulation with forskolin or SIN-1A. Analysis of the sensitivity of MRP8-overexpressing cells revealed that they are ...