D.JenkinsM.A.PennySpringer-VerlagDiabetologiaMijovic C.H., Jenkins D., Penny M.A. 1993. Susceptibility to type 1 (insulin dependent) diabetes mellitus is determined by MHC class II molecules. What about DR4? Diabetologia 36: 1210-1211
To study whether insulin resistance in Type 2 (non-insulin-dependent) diabetes mellitus is due to a defect in the expression of the insulin-responsive glucose transporter gene (GLUT-4) in human skeletal muscle, we measured the level of GLUT-4 mRNA and (in some of the subjects) its protein...
Insulin resistance and reactive hyperinsulinemia occur not only in patients with obesity, impaired glucose tolerance or non-insulin-dependent (Type 2) diab... U Krishnan,J Haythe,E Rosenzweig - 《Vnitr̆ní Lékar̆ství》 被引量: 0发表: 1995年 加载更多来源...
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for...
2Altmetric Metrics Abstract We tested the hypothesis that a particular immune activation profile might be correlated with insulin resistance in a general population. By measuring 43 markers of immune, endothelial, and coagulation activation, we have previously shown that five different immune activation ...
Mechanistically, NGBR overexpression restored insulin signaling of AMPKα1-dependent phosphorylation of AKT and GSK3β. NGBR overexpression also reduced expression of endoplasmic reticulum stress-associated genes in the liver and skeletal muscle to improve insulin sensitivity. Together, our results reveal ...
Intracellular eccDNA SORBS1circle expression was significantly enhanced in the high glucose and palmitate (HG/PA)-induced hepatocyte (HepG2 cell) insulin resistance model. Moreover, the upregulation of eccDNA SORBS1circle in the HG/PA-treated HepG2 cells was dependent on generation of apoptotic ...
We demonstrate the presence of ren -2 transcripts in the small intestine of DBA/2 mice. The marked expression of the ren -2 gene is blunted tissue-specifically by starvation, corroborating a local renin/angiotensin system in this organ.
Adipose tissue dysfunction is considered an important contributor to systemic insulin resistance and Type 2 diabetes (T2D). Recently, a novel family of endogenous lipids, palmitic acid hydroxy stearic acids (PAHSAs), was discovered. These have anti-diabetic and anti-inflammatory effects in mice and...
5K,L). Thus, there seems to be a dose-dependent effect of blocking JH signaling, but the relation of DILP1 to ovarian development is not clear. We also tried to prevent diapause (induce vitellogenesis) and diminish DILP1 expression by feeding or topical application of the JH analog ...