Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the tumor microenvironment, favoring immunosuppression and tumor growth. We discovered, through an unbiased proteomics screen
Immunotherapy is considered a major breakthrough in the treatment of small cell lung cancer (SCLC), although its anti-tumor efficacy is limited. With a high degree of malignancy and high heterogeneity, SCLC is difficult to treat in the clinic. A new combination strategy is urgently needed to f...
Immunotherapy or chemotherapy as local therapy of urinary bladder cancer -聽which is the most effective? Report on a meta-analysis of the long-term outcome of randomized studies comparing intravesical mitomycin C versus Bacillus Calmette-Guerin for non-muscle invasive bladder cancer. Eur Urol suppl ...
Chemotherapy: Uses drugs to kill cancer cells. It may be used alone or before or after surgery. Immunotherapy: Boosts the body’s immune system to fight cancer cells. Drugs like Opdivo® (nivolumab) and Yervoy® (ipilimumab) are currently approved for mesothelioma. Radiation Therapy: High-en...
We know [chemotherapy] is effective in rapidly progressing cancers, so wait until we get the results of molecular testing. If the molecular testing results are negative, then we add the immunotherapy. How important is incorporating a multidisciplinary approach to patient care in NSCLC? ...
Doctors use a combination of imaging tests, blood tests, and biopsy results to diagnose lung cancer. Your choice of treatment depends on the type and stage of cancer you have, as well as your health. Surgery, radiation, chemotherapy, immunotherapy, and targeted therapy are just some of the ...
Immunotherapy:If chemotherapy or targeted therapy doesn’t work, your doctor may try immunotherapy. These drugs help your immune system fight cancer. Radiation therapy:High doses of radiation, such as X-rays, kill cancer cells or keep them from growing. This therapy can treat lung cancer that ...
i) Double immunotherapy treatment.Following the CheckMate trail, two immunotherapy drugs Nivolumab and Ipilimumab started to be used as the first line drug treatment in non-resectable mesothelioma. Three year survival rates were extended to 23% against the traditional chemotherapy drug survival of 15%...
Furthermore, NCT05507606 trial has been designed to evaluate the efficacy of the combination of osimertinib, bevacizumab and platinum-doublet chemotherapy in previously untreated EGFR-mutated NSCLC patients. 5.4. EGFR TKI + immune checkpoint inhibitor (ICI) The combination of EGFR and immunotherapy has...
There are several examples of oncogenic or tumor-suppressive circRNAs in cancer.84They have gained attention in the context of resistance to traditional chemotherapeutic drugs, as well as targeted and immunotherapy approaches.85,86Extensively studied as diagnostic, prognostic, and predictive biomarkers,83...