Similarly, a predicted 2β-dioxygenase (EC1.14.11.13) (MVLG_00840) could be involved in gibberellin inactiva- tion via hydroxylation, although this protein falls more generally into the 2OG-Fe(II) oxygenase superfamily. Another potential set of pathways for plant signaling involves the production ...
The demonstration by EPR that the Dp44mT-iron complex is redox-active confirms our previous studies using cyclic voltammetry, ascorbate oxidation, benzoate hydroxylation and a plasmid DNA strand-break assay. We discuss the relevance of the redox activity to the biological effects of Dp44mT.Jansson...
AURKA molecules cluster across centrosomes that increases their local concentration at centrosomes. As AURKA possesses a conserved redox-sensitive C290 residue in its catalytic domain, the highly oxidative
reaching various subcellular and cellular components. Among them hydroxyl radicals, produced from H2O2in the Fenton reaction, have been shown to induce lipid peroxidation of cellular membranes25,26, conformational changes as well as hydroxylation of chromatin27, and to increase cellular viscosity16,28. ...
elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107(1), 43–54 (2001). Article CAS PubMed Google Scholar Ivan, M. et al. HIF alpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O-2 ...
conformational changes as well as hydroxylation of chromatin27, and to increase cellular viscosity16,28. More recently, ROS have also been implicated in regulating the filamentous actin (F-actin) cytoskeletal network29, and affecting microtubule stability by indirectly controlling α-tubulin levels throug...
Oxidative Perhydroxylation of [c[oso-b 12 H 12 ]2-to the Stable Inorganic Cluster Redox System [b 12 (oh)12]2-1.-: Experiment and Theory** The icosahedral dodecahydro-closo-dodecaborate dianion, [closo-B 12H12F-, is the most prominent member of the hydridoborate cluster family. Its...
(fish, eggs, fortified milk, and mushrooms). The active form of vitamin D, calcitriol (1,25-dihydroxy vitamin D3), formed following kidney and liver hydroxylation, is most renowned for its regulating role in calcium homeostasis and bone health status, but it has also been shown to regulate...
A. Determinants of regioselective hydroxylation in the fungal polysaccharide monooxygenases. J Am Chem Soc 136, 562–565 (2014). 34. Westereng, B. et al. The putative endoglucanase PcGH61D from Phanerochaete chrysosporium is a metal-dependent oxidative enzyme that cleaves cellulose. Plos One 6, ...
Lignin biosynthesis is evolutionarily conserved among higher plants and features a critical 3-hydroxylation reaction involving phenolic esters. However, increasing evidence questions the involvement of a single pathway to lignin formation in vascular plants. Here we describe an enzyme catalyzing the direct ...