This is especially relevant in cases where salt formation is not a viable option (i.e., in cases where there is no ionisable group on the drug). There continues to be much debate regarding the definition of co-crystals, including whether solvates and hydrates are included in the same ...
Our data further support the rationale of combining APR-246 with cisplatin in NSCLC, since their synergistic interaction is retained or enforced under hypoxic conditions in the presence of mutant p53. Keywords: p53; HIF-1α; cisplatin resistance; hypoxia; NSCLC 1. Introduction Lung cancer remains ...