Competence for natural transformation is a central driver of genetic diversity in bacteria. In the human pathogen Streptococcus pneumoniae, competence exhibits a populational character mediated by the stress-induced ComABCDE quorum-sensing (QS) system. H
Competence for natural transformation is a central driver of genetic diversity in bacteria. In the human pathogen Streptococcus pneumoniae, competence exhibits a populational character mediated by the stress-induced ComABCDE quorum-sensing (QS) system. H
The integrity of myelinated axons relies on homeostatic support from oligodendrocytes (OLs). To determine how OLs detect axonal spiking and how rapid axon–OL metabolic coupling is regulated in the white matter, we studied activity-dependent calcium (Ca2+) and metabolite fluxes in the mouse optic...
During blood-stage growth, P. falciparum internalizes hemo- globin in an endocytic process known as host cell cytosol uptake (HCCU) (Aikawa et al., 1966; Spielmann et al., 2020). En- docytosed hemoglobin is transported within vesicles to ...
About 100 people died and more than 300 hospitalized in a span of few years in a village of 1200 people in a tribal stretch in central India. Medical teams visiting the area reported severe renal failure and blamed the local eating and drinking habits as causative factors. This human health...
Raw passion fruit is strongly acidic. Therefore, commercial passion fruit juice typically has been subjected to deacidification by electrodialysis or other means and might have added sugar. Hawaiian lilikoi butter, which normally is made from sugar and passion fruit juice, puree or concentrate, and ...
We hypothesize that monocyte hyporesponsiveness in human sepsis is associated with a downregulation of the pattern recognition receptors Toll-like receptor (TLR)-2 and TLR4. Protein expression of CD14, TLR2 and TLR4 on blood monocytes was examined using flow cytometry from 29 patients with sepsis ...
Recombinant human (rh) Prdx6 (or rh-wt) and the two mutants (rh-C47S and rh-S32A) were produced by expression in Sf-9 cells and purified by Ni2 + affinity chromatography [12]. The peroxidase and PLA2 activity of rh-wt protein have been described by us and others [11], [12],...
intestine impairs the absorption of carbohydrates, resulting in increased transmission of carbohydrates to colon bacteria, which could proliferate and form an acidic environment conducive to D-lactate production. Although both L-lactate and D-lactate can pass through the blood-brain barrier, unlike L-...
However, pH 2 is not representative of the pH that CPPs may be exposed to when in contact with cells, either pH 7.2 outside the plasma membrane, or pH between 6.5 and 4.5 while inside acidic endosomes. In order to establish the relative hydrophobicities of d(X)TAT peptides at these ...