It is discussed why some, but not all HLA-B27-positive persons get disease when triggered by certain infections. The conclusions are that a possible modifying gene may be found on the other HLA haplotype or outside the HLA complex. Given an epidemic infection afflicting a family, it is the...
This study retrospectively examined the impact of a single-nucleotide polymorphism (rs2275913, G197A) in the IL-17 gene of a total 510 recipients with hematologic malignancies and their unrelated donors on the clinical outcomes in HLA-matched myeloablative (discovery study) and nonmyeloablative (...
Background The response to TNF-blockers in axial spondyloarthritis (AxSpA) is at least partially influenced by HLA-B27 through a still poorly understood mechanism. Objectives Given that HLA-B27 regulates the gut microbiota composition in rats1,2, we seek to evaluate the predictive value of the ...
As expected, AIM2 was found to be the most upregulated gene, with a slightly higher expression level in subclone B8 (Supple- mentary Table 2). A number of induced genes appear to be linked to the immunomodulating function of AIM2, such as the IFN-stimulated genes (ISGs) HLA-DRA, HLA-...
The vIL-10-producing lytic-cycle cells can be recognized by CTL because certain CTL clones targeted the vIL-10 peptide (residue 3-11) RRLVVTLQC in the context of HLA-B27 [36]. The functions of the mutated vIL-10 genes remain to be studied. The sequence variation of vIL-10 found in ...
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Fernandez MA, et al., Beta2-microglobulin gene mutation is not a common mechanism of HLA class I total loss in human tumors. Int J Clin Lab Res, 2000. 30(2): p. 87-92.M. A. Fernández,F. Ruiz-Cabello,M. R. Oliva,T. Cabrera,P. Jimenez,M. A. López Nevot,F. Garrido.β2-...
Spondylitis is a condition in which a person experiences chronic pain and general discomfort in the upper and lower back, which...
While there is no known specific cause for this disease, genetics do seem to play a significant role. In fact, people who have a gene called HLA-B27 are at a greater risk for developing ankylosing spondylitis. As the disease worsens, new bone will form as a response by the body in an...
its presentation usually correlates with inflammation in the gut. Moreover, enteropathic arthritis is a diagnosis of exclusion. Interestingly, it has been strongly associated with a specific gene,HLA-DR103,which controls the immune response....