Background & Aims: Hepatic steatosis (HS) seems common in patients infected with human immunodeficiency virus (HIV). However, the relative effect of HIV, as well as hepatitis C virus (HCV) in those co-infected, and the influence of HS on liver fibrosis progression are unclear.Pembroke, ...
Summary. Liver steatosis, diabetes mellitus and hepatitis C virus (HCV) genotype have been implicated in liver fibrosis in HCV-related chronic active hepatitis (CAH). The aim of this study was to evaluate whether steatosis and diabetes were associated with more severe liver fibrosis in patients...
Moreover, we have also shown its relevance in human liver fibrosis associated with different etiologies (obesity, non-alcoholic steatohepatitis, viral hepatitis C and alcoholism). In particular, we have demonstrated a significant positive correlation between the stage of liver fibrosis and HSC ...
A total of 135 patients (46.6%) had steatosis. Liver steatosis, in multivariate analysis, was associated with hepatitis C virus genotype 3, higher grade of necroinflammation, and higher BMI. There was no significant association between stage of fibrosis and liver steatosis. In multivariate analysis...
INTRODUCTION: Chronic hepatitis C is the main cause of death in patients with end-stage liver disease. Prognosis depends on the increase of fibrosis, whose progression is twice as rapid in men as in women. Aim of the study was to evaluate the effects of reproductive stage on fibrosis severity...
aHepatitis, hepatic fibrosis and hepatocellular carcinoma (HCC) are the main liver diseases, threatening the health of human beings. Especially, HCC is one of the most common cancers worldwide and among the leading causes of cancer-related death [1] arises in the setting of chronic liver diseas...
Alternatively, liver injury could have a more integral role wherein cirrhosis drives systemic inflammation, endothelial dysfunction and HFpEF. We hypothesized that liver fibrosis is associated with both HFpEF and HFrEF. Further, we assessed whether HIV and hepatitis C status modified the association of...
aHepatitis C is a viral hepatitis is common in clinical practice, the pathogen of hepatitis C virus (HCV) infection, can cause liver acute and chronic inflammation, very few developed severe hepatitis. Blood transfusion and blood products was the route of transmission of hepatitis C is the most...
The IFNL3/4 locus influencing innate immunity regulation has been associated with the severity of hepatitis and fibrosis progression during chronic hepatitis C infection, while contrasting results were reported in NAFLD. In this study, we examined whether rs12979860 and the linked causal rs368234815 ...
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