Intravenous unfractionated heparin 5000 U was administered immediately after atrial transseptal puncture and followed 1000 U/h to maintain an activated clotting time (ACT) of 300-350 S, the ACT level was monitored every 30 min. In addition, heparinized saline solution was continuously infused through...
The model is based on antico- agulation with lepirudin, a recombinant hirudin analogue that is a highly specific thrombin inhibitor that does not influence complement activation, in contrast to heparin. Whole blood was collected in polypropylene tubes that contained lepirudin (50 g/mL) and ...
The charge-based prodrug behavior was self-assembled via the strong electrostatic binding between the polyanionic heparin motif on the targeting component and the poly-cationic CPP on the drug component. Both systems possessed dual active- (via the antibody or an external magnetic force) and passive...
(C–C motif) ligand 2 Cysteine-rich protein 61, connective tissue growth factor and nephroblastoma overexpressed Connective tissue growth factor Dickkopf-1 Macrophage-colony stimulating factor Granulocyte macrophage-colony stimulating factor Heparin-binding epidermal growth factor Insulin-like growth factor ...