Hemolysis is common in all extracorporeal circuits as evident by the elevated plasma free hemoglobin (PFHb) level. We investigated whether increased hemolysis during extracorporeal membrane oxygenation (ECMO) is an independent mortality predictor. We performed a retrospective observational study of consecutiv...
Is plasma free hemoglobin a legitimate target for therapeutic plasma exchange?Raval, J SDargo, GWearden, P DOrr, R AKiss, J E
These data also support the premise that lipid peroxidation per se plays a role in glycation of hemoglobin and plasma proteins. 展开 关键词: Hypertension Lipid peroxides Glycated hemoglobin Fructosamine DOI: 10.1016/j.arcmed.2007.05.008 被引量: 26 ...
Haptoglobin-related protein (Hpr) is a primate-specific plasma protein associated with apolipoprotein L-I (apoL-l)-containing high-density lipoprotein (HDL) particles shown to be a part of the innate immune defense. Despite the assumption hitherto that Hpr does not bind to hemoglobin, the present...
Hemolysis-associated anemia is characteristic of diseases such as atherosclerosis, lupus, malaria, and leishmaniasis; the toxic effects of free hemoglobin (Hb) have been extensively described. This study was based on the premise that release of this sequestered, inflammatory molecule can result in del...
Hemoglobin Glycation Index Is Associated With Cardiovascular Diseases in People With Impaired Glucose Metabolism. There is a substantial interindividual variation in the association between glycated hemoglobin (HbA1c) and plasma glucose concentrations. Its impact on ca... Chang,Ho,Ahn,... - 《Journal ...
Oxygenated blood has two means of ferrying oxygen to the tissues of the body: dissolved in the blood plasma or attached to the hemoglobin within red blood cells. Hemoglobin-oxygen combinations typically account for about 98.5 percent of the oxygen transported from the lungs throughout the body. ...
RDW was inversely associated with hepcidin, FtL, and hemoglobin. The risk of VTE increased linearly across categories of higher plasma hepcidin levels. Participants with hepcidin in the highest quartile had an OR for VTE of 1.32 (95% CI, 1.00-2.42), and those in the >90% percentile had an...
Resistance artery vasodilation in response to hypoxia is essential for matching tissue oxygen and demand. In hypoxia, erythrocytic hemoglobin tetramers produce nitric oxide through nitrite reduction. We hypothesized that the alpha subunit of hemoglobin e
Heme is an essential component of several proteins in the organism including hemoglobin, mitochondrial cytochromes and NO synthase. Whereas a low heme synthesis is responsible for porphyria1, heme intracellular accumulation is likely to be also deleterious through induction of intracellular oxidative stress...