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Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD). Conditions of stress or injury induce APOE expression within neurons, but the role of neuronal APOE4 in AD pathogenesis is still unclear. Here
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Isoniazid (INH) is a first-line anti-tuberculosis drug used for nearly 70 years. However, the mechanism underlying the side effects of INH has remained elusive. Here, we report that INH and its metabolites induce a post-translational modification (PTM) o
Metformin, a type 2 diabetes treatment, improves the cognitive function of aged mice; however, whether the protective effects of metformin on cognitive function in aged mice are associated with the gut microbiome is poorly understood. Although some studi
All/RealPhoto60/LQ' --save_dir ./results-Q --SUPIR_sign Q --upscale 2 # for light degradation and high fidelity CUDA_VISIBLE_DEVICES=0,1 python test.py --img_dir '/opt/data/private/LV_Dataset/DiffGLV-Test-All/RealPhoto60/LQ' --save_dir ./results-F --SUPIR_sign F --upscale ...
Isolated leukocytes from healthy untreated animals (4 × 106 cells/well in a 96-well plate) were cultured for 48 h with various Cd concentrations (1, 5, 10, and 50 μmol/L) alone and in the presence of 3 µmol/L of the AhR antagonist CH-223191 (Sigma-Aldrich) to determine cytokin...
MII oocytes were harvested by digestion in hyaluronidase (H4272, Sigma-Aldrich). Cumulus cells were removed by capillary washing in PBS and zygotes were cultured in EmbryoMax KSOM Medium (1X) w/ 1/2 Amino Acids (Merck Millipore) or KSOMAA (Ho et al., 1995) at 37°C and 5% CO2. ...
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