Hypertrophic cardiomyopathy (HCM) is commonly caused byinheritedfaulty genes (unit of heredity). In this disease, more than 1,400 gene changes (mutations) occur in the heart muscle. People with HCM often have a pattern of inheritance on a pair of autosomal chromosome (non-sex chromosome). Wha...
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Although it is an autosomal inherited disorder, HCM is more prevalent in men, and women with HCM have delayed onset of symptoms and slower disease progression (45). A biologic explanation for the sex difference has been studied in a mouse model of HCM that expressed a R92 mutation in which...
Coronary heart disease (CHD) is a group of different types of heart disease. Common heart disease symptoms include chest pain, shortness of breath, palpitations, light-headedness, and dizziness. Heart disease has many causes, including genetics, atherosc
BACKGROUND: (HCM) is a disease of the heart muscle, with an autosomal dominant mode of inheritance. It is also known as the 'disease of the ', and is a maj... R Advithi,R Deepa Selvi,S Ml,... - 《Experimental & Clinical Cardiology》 被引量: 22发表: 2012年 Alpha-cardiac actin...
Hypertrophic cardiomyopathy (HCM) is a common, heritable form of heart disease that leads to sudden death in people of all ages1. A variety of mutations for HCM have been identified, most commonly involving genes which encode the sarcomeric apparatus2; however, studies have reported varied positiv...
Coronary heart disease (CHD) is a group of different types of heart disease. Common heart disease symptoms include chest pain, shortness of breath, palpitations, light-headedness, and dizziness. Heart disease has many causes, including genetics, atherosc
As shown in Table 1, the included patients were mainly complicated with valvular disease, obstructive hypertrophic cardiomyopathy (HCM), coronary heart disease and aortic disease. Some patients had increased atrial afterload caused by valvular disease and HCM. Table 1 The baseline characteristics of ...
Hypertrophic cardiomyopathy (HCM) is a condition where the heart (cardio) muscle (myopathy) becomes thickened (hypertrophied). HCM is the most common type of genetic cardiomyopathy. Patients are born with a gene that makes the heart muscle thicker than i
Valsalva maneuver underestimated the presence and magnitude of exercise-induced obstruction.Conclusions— Among those patients who come to clinical evaluation, HCM is a predominantly obstructive disease in which LV outflow gradients, frequently associated with heart failure symptoms and often identified only...