Ribavirin induced hemolysis is haptoglobin dependentdoi:10.1016/S0016-5085(00)85932-6Van Vlierberghe, HansDelanghe, JorisDe Vos, MartineLeroux-Roels, GeertElsevier Inc.Gastroenterology
In normal conditions, the rate of RBC destruction is matched by the rate of formation of new RBCs in the bone marrow. However, excessive hemolysis can cause a low number of RBCs in blood and lead to hemolyticanemia. Read on for more information on what is hemolysis, the types of hemolysis...
Fig. 7. Inhibition studies of DNA cleavage in presence of haptoglobin (Hp) as determined by agarose gel electrophoresis. The HbA was incubated with Hp, followed by addition of pDNA, agarose gel electrophoresis of different ratios of Hp:Hb. lane 1, Hb+pDNA+Hp (0.5 µM, 1:1.25); lane...
Serum haptoglobin Indirect bilirubin Coombs test The hemolysis index, which measures the red color of the serum A high index means there is a large amount of free hemoglobin, indicating hemolysis. However, this may also happen from mishandling of the blood sample, hence caution is required. Dia...
Plasma Haptoglobin Level in Twins: Kyung-Sook Park: Eiji INOUYE and Akio ASAKA(Inst. Brain Res., Univ. Tokyo, Tokyo) Subjects are 61 monozygotic (MZ), 8 same-sexed dizygotic (DZ), 3 different-sexed dizygotic twin pairs aged 11 to 12 years, and 66 fathers and 68 mothers. Twins are ...
CD163 mediates the internalization of hemoglobin-haptoglobin (Hb-Hp) complexes by macrophages. Because Hp binding capacity is exhausted during severe hemolysis, an Hp-independent Hb-clearance pathway is presumed to exist. We demonstrate that Hb interacts efficiently with CD163 in the absence of Hp....
The limits of detection for the murine markers were: haemopexin 125–16,000 ug/mL, haptoglobin 39–5000 ug/mL and haemin 0.2–8.4 uM. Statistical analysis Survival was analysed using the log-rank test; repeated measures ANOVA was used to compare levels of murine haemopexin or haptoglobin ...
(alpha-glucosidase) Interleukin 8 receptor, alpha Haptoglobin-related protein Colony stimulating factor 3 (granulocyte) Serum amyloid A2 Fc fragment of IgG, low affinity IIIa, receptor for (CD16) Fold change 322.4 209.4 85.9 84.67 83.22 67.91 67.3 65.89 52.63 51.65 46.05 45.09 39.56 38.27 38.24 ...
208470_s_at Haptoglobin-related protein 36.4 0.00944 207442_at Colony stimulating factor 3 (granulocyte) 35.62 0.00485 208607_s_at Serum amyloid A2 32.18 0.00316 204007_at Fc fragment of IgG, low affinity IIIa, receptor for (CD16) 29.33 0.00066 Table 3. Ten probe sets with largest negative fo...
CD163 mediates the internalization of hemoglobin-haptoglobin (Hb-Hp) complexes by macrophages. Because Hp binding capacity is exhausted during severe hemolysis, an Hp-independent Hb-clearance pathway is presumed to exist. We demonstrate that Hb interacts efficiently with CD163 in the absence of Hp....