Cells exposed to H2O2 respond with induced Hebp2 expression, and its activation triggers the release of cytochrome c. Conversely, its silencing protects from apoptosis [130]. A further example relates to an upregulation of tumor protein p53-inducible nuclear protein-1 (Tp53inp1). Tp53inp1 is a ...
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Furthermore, the interaction between GLB-12 and these two SODs adds a surprising third level of regulation in this redox signal, whereby the amount of O2. À and H2O2 on the intra- and extracellular side of the plasma membrane are important determinants of the downstream signal. It is ...
Responses of cells grown in DDW or DEW to auranofin (E) or H2O2 (F) treatment. G, Dynamic ROS production in cells grown in DEW, DDW or treated with 3 μm auranofin. H, Model of D regulation for cell growth. C-G show mean ± S.E. with four replicates measurements. *p < 0.05,...
We used the lysosomotropic probe acridine orange (AO), a metachromatic fluorophore, which mainly accumulates in acidic organelles and displays, at high concentration, a red to orange fluorescence when excited by blue light. On lysosomal rupture, the dye is released into the cytosol where its ...
Why do the bodies cells become more acidic as a result of cellular respiration? Why is O2 required for cellular respiration? Why does wood burn more rapidly in pure oxygen than in air? Why benzene burns with intense smoky flame? Explain why Aldehydes are more reactive than ...
Both sulfoxides and sulfones are readily formed when all three Met(E11) Hb variants are reacted with high levels of H2O2 regardless of the initial iron oxidation state. An acidic environment may cause decomposition of the sulfoxide to form an aldehyde and a methylmercaptan (steps 3–6). ...
The OH• radical studies were performed in the presence of H2O2 (1 M) and TA (1 mM), which was the capture probe.41 The reaction mixture was independently exposed to the six wavelengths of light (intensity of 4.5 mW cm−2). TA is a non-fluorescent compound that specifically reacts...
stress-mediated cell death G Caputa1, S Zhao1, AEG Criado1, DS Ory1, JG Duncan2 and JE Schaffer*,1 RNASET2 is a ubiquitously expressed acidic ribonuclease that has been implicated in diverse pathophysiological processes including tumorigeneis, vitiligo, asthenozoospermia, and neurodegeneration....
Ascorbate has an antioxidant action for detoxification; active oxygen is converted to H2O2 in the stroma by superoxide dismutase and the H2O2 is then converted to H2O by ascorbate peroxidase3,4. On the other hand, b-carotene is an accessory pigment of LHC2, and it has been reported that b...