Males are generally more susceptible to impaired glucose metabolism and type 2 diabetes (T2D) than females. However, the underlying mechanisms remain to be determined. Here, we revealed that gut microbiome depletion abolished sexual dimorphism in glucose metabolism. The transfer of male donor microbiota...
The relationship between the amino acid and glutathione (GSH) metabolism was shown by Noctor et al. (1998). The overexpression of the gene encoding γ-glutamylcysteine synthetase, the first enzyme of GSH synthesis increased not only the level of GSH, but also that of some free amino acids. T...
Jensen, A.P. Herman, T. Hansen, O. Pedersen, J.J. Holst, B.L. Langdahl, A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk, J. Clin. Endocrinol. ...
Measurements of glucose changes over time were performed in the same experimental design as described above (see Cell proliferation assay) using a blood glucometer (Contour® plus ONE ref. 84,656,348, Ascensia Diabetes Care AG) and dedicated strips (Contour® plus ref. 84,581,896, Ascensia...
Briefly, freshly isolated thoracodorsal arteries were placed in ice-cold Krebs-HEPES solution containing 118.4 mM NaCl, 4.7 mM KCl, 1.2 mM MgSO4, 4 mM NaHCO3, 1.2 mM KH2PO4, 2 mM CaCl2, 10 mM HEPES, and 6 mM glucose. The vessels were then mounted in a ...
The majority of studies that have examined the interactions between glutamate, insulin and glucose are in vivo and have focused on the insulin response that is elicited when glutamate is elevated in circulation or in a given tissue. Few studies have investigated the effects of glutamate on glucose...
Glucose Modulation of Amino Acid-Induced Glucagon and Insulin Release in the Isolated Perfused Rat Pancreas Interactions between glucose and arginine and a mixture of 20 amino acids found in normal rat serum were studied in the isolated perfused rat pancreas of normal rats, with release of immunorea...
2.2. A Glucose-Free, High-Protein Diet Increases Amino Acid Metabolism and Decreases Lactate and Insulin Production To investigate the effect of GFHPD consumption on systemic and colonic metabolisms in AOM/DSS-treated mice, we analyzed metabolic markers in serum and colonic biopsy samples collected ...
A boost in collagen may help increase your metabolism byaddinglean muscle mass to your frame and helping with the conversion of essential nutrients. One of glycine’s most important roles is helping form muscle tissue by converting glucose into energy that feeds muscle cells. Remember that retainin...
Hosios, A. M. et al. Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells. Dev. Cell 36, 540–549 (2016). CAS PubMed PubMed Central Google Scholar Commisso, C. et al. Macropinocytosis of protein is an amino acid supply route in Ras...