The principal capsular component, glucuronoxylomannan, displays immunomodulatory activities, including reduction of neutrophil anticryptococcal activity, induction of monocyte IL-10 production, and disruption of dendritic cell maturation and activation.135 C. neoformans produces melanin from phenolic substrate...
This is consistent with values reported for rodent neocortex25 and suggests that the movement of 4 kDa FITC-dextran in the cortex is predominantly by diffusion, a con- clusion previously reached by others11,18,19. Notably, these results show that diffusion kinetics do not change during sleep...
While this could be a good setup for short baseline stereo, it does not work well for wide baseline, where affine features are usually sought. Finally, we propose the hard negative-constant loss instead of the contrastive one. 2 Learning Affine Shape and Orientation 2.1 Affine Shape ...
Gut microbiota also affect deglucuronida- tion of androgens and intestinal metabolism [76]. But we did not find significant effect of transplanted microbes on serum T level; however, the trend in recipient voles was similar to that in donor voles, likely caused by insufficient sample size. ...
Within this genus, the anther-smut fungi of plants in the Caryophyllaceae, con- sist of many recognized and cryptic species, most pos- sessing a very narrow host range, although some are more generalist [2]. Hybrid incompatibilities for the spe- cies examined in this complex leads to post...
6A, Gb3 formed hydrogen bonds with ASP231 of chain B and GLU35 of chain A of the protein dimer, and hydrophobic interactions with PHE229, MET51, and TRP47 of chain B, as well as with GLN357 and ILE359 of chain A. The binding energy between Gb3 and the mutant protein dimer was ...
This revealed that N167, L170 and H174 are each essential for VCF1 binding to p97 (Fig. 2c). Of note, these residues are all highly con- served among VCF1 orthologs and reside on the same face of the α- helix (Fig. 2d; see also Fig. 3b). Mass spectrometry-based comparison of...
Furthermore, while stimulation with mito- gens can enhance glutamine utilization in various cell types, neither the signaling pathways responsible for this activity nor the specific pathways of glutamine metabolism (e.g., glu- taminolysis vs. glutamine-based anaplerosis) have been characterized.15,17...
For the flat plate-like structures, they may be considered as an additional layer of different material that is attached or integrated with the plate. During the lifetime of the component, cracks may form inside the adhesive or coating or at the interface to the 186 D. G. Aggelis et al...
The mechanisms through which obesity may influence the disease process include an excess production of estrogen by adipose tissue aromatase (peripheral aromatization), re- duced levels of sex hormone-binding globulin with conse- quent rise of the bioactive/free estradiol, increased biosynthesis of ...