Death-associated protein kinase 1 (DAPK1) plays an important role in neuronal apoptosis and could influence the pathology of late-onset Alzheimer's disease (LOAD) and frontotemporal dementia (FTD). It has been reported that two common polymorphisms (rs4878104 and rs4877365) are associated with ...
Symptoms usually show up around age 60 – earlier than they usually start with Alzheimer’s disease. Types of frontotemporal dementia include behavioral variant FTD (bvFTD), primary progressive aphasia, Pick's disease, corticobasal degeneration, and progressive supranuclear palsy. Creutzfeldt-Jakob disea...
Most Alzheimer’s Disease (AD) cases also exhibit limbic predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC), besides amyloid-β plaques and neurofibrillary tangles (NFTs) containing hyperphosphorylated tau (p-tau). LATE-NC is characterized by cytoplasmic aggregates posit...