Complex problems are problems with lots of variables interacting in complicated ways. Modeling the behavior of individual atoms in a molecule is a complex problem, because of all the different electrons interacting with one another. Identifying new physics in a supercollider is also a complex problem...
S1b). TM9SF4 knockdown substantially increased cell size and enhanced actin stress fiber formation in A2780, CaOV3, OVCAR3, COV362, SKOV3, MCF-7 and T47D cells, all of which have high endogenous expression levels of TM9SF4 (Fig. 1c–e and Fig. S2), while the expression level of ...
invasion. A 2021 study reported that AITC inducedER+/PR+breast cancer cell death in a dose-dependent manner by causing DNA damage and altering DNA damage repair proteins. AITC has also been shown to reduce Adriamycin (doxorubicin)-induced heart damage (cardiomyopathy) in a rat model of ...
Here, we ask the simplest question related to the response of a biomolecular condensate to its environment: how does its phase behavior and internal structure respond to the crowding effect of other macromolecules? Naively adding additional molecule types as crowding agents multiples the parameters ...
which indicates that the calibration model must not develop for this molecule below the value of 0.56 µg/cm2. Some molecules may have higher or lower RAL. Therefore, LOQ might change for that particular molecule. It is recommended that a LOQ study is performed for each molecule separately ...
Complex problems are problems with lots of variables interacting in complicated ways. Modeling the behavior of individual atoms in a molecule is a complex problem, because of all the different electrons interacting with one another. Identifying new physics in a supercollider is also a complex problem...
To further characterize the kinetics of histone tail–DNA interactions, we count a total number of transitions from unbound to bound states and compute histone tail residence time to estimate the effective time that histone tails stay bound to the DNA molecule (as the inverse of the dissociation ...
Intercellular adhesion molecule VCAM: Vascular cell adhesion molecule TNFα: Tumor necrosis factor alpha IFNγ: IFN gamma. CRP: C-reactive protein oxLDL: Oxidized low density lipoprotein AGEs: Advanced glycation end-products NF-κB: Nuclear factor-κB RAGE: Receptor for advanced glycation...
elastic fiberprincipal component analysisstructural ensemblestructural proteintropoelastinTropoelastin is the dominant building block of elastic fibers, which form a major component of the extracellular matrix, providing structural support to tissues and imbuing them with elasticity and resilience. Recently, ...
Stromal interaction molecule (STIM) proteins are a family of Ca2+sensors located in the S/ER membrane that are activated by S/ER Ca2+store depletion [56,117]. STIM proteins share a common domain structure that includes the EF-SAM domain in the N-terminus (a single pass transmembrane domain...