elastic fiberprincipal component analysisstructural ensemblestructural proteintropoelastinTropoelastin is the dominant building block of elastic fibers, which form a major component of the extracellular matrix, providing structural support to tissues and imbuing them with elasticity and resilience. Recently, ...
S1b). TM9SF4 knockdown substantially increased cell size and enhanced actin stress fiber formation in A2780, CaOV3, OVCAR3, COV362, SKOV3, MCF-7 and T47D cells, all of which have high endogenous expression levels of TM9SF4 (Fig. 1c–e and Fig. S2), while the expression level of ...
To quantitatively measure the vimentin-microtubule colocalization, we next use STORM microscopy which gives single-molecule details and a resolution of 20 nm in the X-Y plane (Fig. 4b). The analysis of our STORM images shows that a large fraction of microtubules colocalizes with vimentin fil...
ON-A-MOLECULEAQUEOUS-MEDIAMERCURY IONSFLUORESCENCE SENSORRECEPTORARRAYSCHEMODOSIMETERIMMUNOSENSORPROBEWATERFor remote Hg2+ detection, an array of nanotips was covalently functionalised using a versatile photochemical approach. After chemical etching of an optical fiber bundle to generate the nanotip array, a ...
Quantum computing is a rapidly-emerging technology that harnesses the laws of quantum mechanics to solve problems too complex for classical computers.
Heterodimerization of TRPV1 with TRPA1 (Akopian, 2011), a molecule implicated in mechanical sensitization of primary afferents (Dunham et al., 2008, Lennertz et al., 2012), may explain, in part, the TRPV1 agonist effects on mechanical nociception. Of course, we cannot exclude the ...
We model each Rubisco as a sphere with 4 small spherical binding sites on each end, and each EPYC1 molecule as a polymer with 3, 4, or 5 binding sites (Figures 7G–7I; Movie S6). When the EPYC1 and Rubisco binding sites overlap, specific bonds are formed (see below). We simulate...
IBM provides quantum computing technologies including Qiskit SDK and Qiskit Runtime for scalable and performance-oriented quantum computing. IBM Quantum Computing Solutions Bringing useful quantum computing to the world through Qiskit Runtime and IBM Quantum Safe. IBM Quantum Safe Services Safeguard your...
It is therefore possible that the levels of mAgrin expressed via AAV-mediated gene delivery are not optimal, preventing its effective binding to the fiber membrane as indicated in the cell assay. This could be tested with a series of AAV dosages expressing low-to-high levels of mAgrin; ...
If you could look at a polymer chain close up, you would see that the visual structure and physical properties of the molecule chain mimic the physical properties of the polymer. For example, if a polymer chain comprises tightly twisted bonds between monomers that are difficult to break, the ...