Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat. Med. 24, 647–657 (2018). Article CAS PubMed PubMed Central Google Scholar Lin, Y.-T. et al. APOE4 causes widespread molecular and cellular alterations ...
We previously identified endothelial cell-selective adhesion molecule (ESAM) as a novel functional marker of hematopoietic stem cells in mice. Here, we found that ESAM can also be used to purify human hematopoietic stem cells from all ... T Ishibashi,T Yokota,H Tanaka,... - 《Experimental He...
To rationalize the impact of nucleosome breathing in chromatin self-assembly, we quantify the average number of DNA base pairs that unwrap from each nucleosome due to thermal fluctuations as a function of the NaCl concentration (Fig.3d). In vitro, single-molecule (sm) fluorescence resonance energy...
Inaccessibility of biotinylated concanavalin A to the native elementary unit and partial dissociation of the elementary unit after incubation with excess N-glycosidase F or endoglycosidase H suggest that a single molecule of P25 is located internally and plays an important role in maintaining integrity ...
bondNature of the bonding in isolated XeOF2 molecule and F2OXeNCCH3 molecule appears as a weakly bound intermolecular complex. Intermolecular interaction energy components have also been studied using Symmetry Adapted Perturbation Theory. 2016 Wiley Periodicals, Inc....
A reported experimental vibrational frequency at 734 cm(-1) was verified computationally to be the F-F stretching mode of the end-on coordinated F2 molecule. This result is in line with the recently published trends in the highest attainable oxidation states of the 5d transition metals where Au...
Learning Lab This problem has been solved! You'll get a detailed solution from a subject matter expert that helps you learn core concepts. See AnswerSee Answer Question: Draw the MO diagram of F2+, and also is the molecule diamagnetic or ...
As a standard, solutions with known molecule numbers of a plasmid containing the amplified region were used. The amplification was carried out in an ABI Prism 5700 Sequence Detector (Applied Biosystems) using the following cycling program: 50 °C, 2 min, 95 °C, 10 min, 95 °C, 15 s, ...
(tRNA) adopt very specific, evolutionarily conserved 3D conformations in order to perform translation, and RNA aptamers can specifically recognise small molecules and other ligands by virtue of their 3D structures. The architecture of a structured RNA molecule is hierarchical, whereby the RNA sequence ...
22. PROTACs offer several advantages over classical small molecule inhibitors, as they circumvent the requirement to employ ligands targeting the enzymatic function of the given target protein and they can function in a sub-stoichiometric manner enabling sustained pharmacodynamic effects at lower systemic ...