It has been reported that estrogen receptor beta (ERbeta) signaling participates in inhibiting angiogenesis in breast cancer cells in vitro using transient transfection assay. On the other hand, evidence from ERbeta gene knockout female mouse has demonstrated that, during bone development, ERbeta ...
In mammals, Sox9 has been implicated as a target gene of ERRα in chondrocytes49 and over-expression of ERRα positively regulates the mRNA and protein levels of Sox950. The observed reduction of Sox100B levels in ERR knockdown testes in the present study are consistent with the above. In...
The roles for ERα nuclear actions have been clarified using unique mouse models of ERα, including a model lacking AF-1 function (ERα AF-10 mice) and a model lacking AF-2 function (ERα AF-20 mice), as well as a complete gene deletion model (21,22). In particular, the ...
The estrogen-related receptor alpha (ERRα) is a primary regulator of mitochondrial energy metabolism, function and dynamics, and has been implicated in autophagy and immune regulation. ERRα is abundantly expressed in the intestine and in cells of the i
We found that ARGLU1 (arginine and glutamate rich 1) not only colocalizes with MED1 in the nucleus, but also directly interacts with a far C-terminal region of MED1. Reporter assays indicate that ARGLU1 is able to cooperate with MED1 to regulate estrogen receptor-mediated gene transcription...
Histological evidence suggests that insulin-producing beta (β)-cells arise in utero from duct-like structures of the fetal exocrine pancreas, and genetic lineage tracing studies indicate that they are maintained in the adult by self-renewal. These studi
Poly(ADP-ribose) polymerase 1 is a key regulator of estrogen receptor α-dependent gene transcription. 来自 Semantic Scholar 喜欢 0 阅读量: 142 作者:F Zhang,Y Wang,L Wang,X Luo,K Huang,C Wang,M Du,F Liu,T Luo,D Huang 摘要: Activation of nuclear receptor estrogen receptor alpha (ER ...
The estrogen receptor alpha gene (ESR1) is known to be involved in metabolic pathways influencing growth. We have performed two population-based association studies using three common polymorphisms within this candidate gene to determine whether these are associated with variation in adult stature. In ...
Estrogen receptor-dependent activation of AP-1 via non-genomic signalling. Nucl Recept 2004;14:1–11. Google Scholar Gagliardi M, Maynard S, Miyake T, et al. Opposing roles of C/EBPbeta and AP-1 in the control of fibroblast proliferation and growth arrest-specific gene expression. J Biol...
The female predominance for developing Alzheimer disease (AD) suggests the involvement of gender specific factor(s) such as a reduced estrogen-estrogen receptor signaling in the pathogenesis of AD. The potential role of ERα in AD pathogenesis has been e