median eminence10. GnRH then acts on gonadotrope cells in the anterior pituitary to trigger secretion of the gonadotropins; luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH in turn regulate sex hormone production (i.e., estradiol in females and testosterone in males)...
Sle1b females. Altogether, these results demonstrate that ERα signaling is responsible for the female sex bias in the actions of Sle1b , and is absolutely required for the female-specific B cell hyperactivation phenotype associated with this lupus susceptibility locus. By contrast, we found that...
Potentially associated with FSD is a suite of behavioural, physiological and morphological traits in females that implicates (as a putative mechanism) ‘masculinization’ via androgen exposure; however, relative to conspecific males, female lemurs curiously show little evidence of raised androgen ...
Implementation in clinical practice of sex-tailored cut-off values for hs-cTn represents a hot topic due to the need to reduce inequality and improve diagnostic performance in females. The aim of this review is to summarize current evidence on sex-specific cut-off values of hs-cTn and their ...
found that estrogen negatively affects a highly evolved protective lipid circuit, called "15-lipoxygenase-Lipoxin A4" that has recently emerged as an important protective pathway in many diseases. This pathway balances the activity of pro-inflammatory signals to promote wound healing and to keep ...
In addition, FLX- and CTR-females showed the same amount of paracopulatory behavior and lordosis, both during the full behavioral estrus and the "most active bout". Furthermore, no differences were found in the display of social and conflict behaviors, nor in ER伪 expression patterns in the ...
Most cases of labial fusions occur in infants and young girls: These are known as primary labial adhesions. About 2% of female children are affected by labial fusions due to having low levels of estrogen beforepuberty. These low estrogen levels can also be found in women who have just given...
Polymorphisms of the estrogen receptor ESR1 and ESR2 genes have been linked with cognitive deficits and affective disorders. The effects of these genetic variants on emotional processing in females with low estrogen levels are not well known. The aim was to explore the impact of the ESR1 and ESR...
time point was haphazardly chosen for sequencing. In one family, two females were used for the second time point because no male was found in the respective family. In another family, two males were used for the third time point each because no female could be found in the respective ...
Thus, the phosphorylation site S122 in ERα has a tissue-dependent role in vivo in females. The aim of this study was to investigate if phosphorylation site S122 of ERα has a tissue-specific role also in males by 1) comparing weights of various estrogen-responsive tissues and body ...