Fat intake is associated with serum estrogen and androgen concentrations in postmenopausal Japanese women. J Nutr 2005;135:2862-5Nagata C, Nagao Y, Shibuya C, Kashiki Y, Shimizu H. Fat intake is associated with serum estrogen and androgen concentrations in postmenopausal Japanese women. J Nutr ...
Testosterone deficiency, insulin resistance and the metabolic syndrome. Nat Rev Endocrinol. 2009;5:673–81. Article CAS Google Scholar Mauvais-Jarvis F. Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity. Trends Endocrinol Metab. 2011;22:24...
Results of animal experiments revealed that estrogen (17-β-estradiol, E2) and androgen (dihydrotestosterone, DHT) had opposite effects on body weight gain as well as on the regulation of CAV1, hormone sensitive lipase (HSL) and uncoupling protein 1 (UCP1) in adipose tissues. Furthermore, ...
Estrogen and Bcl-2: gene induction and effect of transgene in experimental stroke. Female rodents producing endogenous estrogens are protected from stroke damage in comparison with male counterparts. This natural protection is lost after ... NJ Alkayed,S Goto,N Sugo,... - 《Journal of Neuroscien...
Few meaningful data are available on the use of testosterone for treatment of postmenopausal women with hypoactive sexual desire disorder not receiving estrogen or estrogen plus progestin. This double-blind, randomized, placebo-controlle... SR Davis,M Moreau,R Kroll,... - 《Obstetrical & Gynecologi...
The role of the androgen receptor (AR) in estrogen receptor (ER)-α-positive breast cancer is controversial, constraining implementation of AR-directed therapies. Using a diverse, clinically relevant panel of cell-line and patient-derived models, we demonstrate that AR activation, not suppression, ...
Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late-onset Leydig cell apoptosis in both mice and mentestistestosteroneestrogensteroidogenesisspermatogenesisLeydig cell number and function decline as men age...
Menopausal symptoms, bone loss, changes in lipid profiles and reduction of insulin sensitivity due to an abrupt decrease in circulating estrogen level are ... Y Toshiyuki,M Sumika,T Anna,... - 《J Med Invest》 被引量: 70发表: 2012年 Androgens in women The role of androgen treatment in ...
There is no direct association of TRT and breast cancer; however, research shows that high levels of testosterone may trigger aromatization- conversion of testosterone to estrogen. This may boost breast tissue receptors increasing the possibility of male breast cancer. More research needs to be done...
Further, the isoforms are regulated by different estrogen receptor (ER)-inducible promotors and have their own response genes, mediating the wide spectrum of physiological effects of progesterone with little overlap9,10. A role of the PGRs in tumorigenesis is now established in several malignancies....