17尾-Estradiol modulates gene transcription through the estrogen receptor and the estrogen response element in DNA. The human transforming growth factor-尾... MM Weissman - 《Jama the Journal of the American Medical Association》 被引量: 3048发表: 1996年 Basic psychopharmacology of antidepressants, ...
aTestosterone is converted to estradiol in adipose tissue by the enzyme aromatase, and the optimal ratio of testosterone to estradiol is >10:1. With the rising 睾甾酮在脂肪组织被转换成estradiol被酵素aromatase,并且睾甾酮优选的比与estradiol是>10 :1. 以上升 [translate] ...
Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver In contrast, the cholestatic estrogen metabolite estradiol-17尾-glucuronide inhibited ATP-dependent taurocholate transport only in normal cLPM and in Bsep/Mrp2... Bruno,Stieger,and...
apoverty 正在翻译,请等待... [translate] aThe reduction of estrone to estradiol could be shown to take place under anaerobic conditions without nitrate (Figure 8 shows the data for the MBR sludge; the experiment with CAS-K sludge is not shown): after spiking E1, a constant ratio of the ...
During a woman’s reproductive life, which starts with the onset of menstruation and continues until menopause, the main type of estrogen produced is estradiol. Enzymatic actions produce estradiol from androgens. Testosterone contributes to the production of estradiol, while the estrone is made from ...
合环使构象固定,影响药效学性质 (药效不变/药效增强/药效降低/产生新药效/活性构象的研究 改变药动学性质,可用于设计前药 作用增强 氯胍前药 环氯胍 estradiol allenestrol diethylstibestrol 开环可能降低药理活性 引入烯键 插烯原理(Vinylogy principle):插烯物 A-(CH=CH)n-B,A、B 之间的电性可通过共轭...
Randomized, placebo-controlled trial of the effects of drospirenone-estradiol on blood pressure and potassium balance in hypertensive postmenopausal women ... Drospirenone (DRSP), a spironolactone analog with aldosterone antagonist activity, is a novel progestogen developed for use as hormone therapy in ...
(0.025 mg kg−1) restored this behavior in these females supplemented with only estradiol (OVX+E) (one-samplettest (H0: mean equals 0);P = 0.01; Fig.4a), whereas an sc injection of Kp-10 failed to elicit a male-directed preference in female (OVX+E+P)GnRH::Cre; Dicer...
Following administration of ampicillin or amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted. Warnings for Amoxil Included as part of thePRECAUTIONSsection. ...
Drug-drug interactions (DDI) with oral contraceptives containing 17伪-ethinylestradiol (EE2) have been well characterized with regard to interactions with phase I drug metaolizing enzymes; however, DDI with EE2 and phase II enzymes have not been as thoroughly addressed. Our laboratory recently ...