Intrauterine growth restriction (IUGR) is associated with reduced kidney size at birth, accelerated renal function decline, and increased risk for chronic kidney and cardiovascular diseases in adults. Precise mechanisms underlying fetal programming of ad
encoding the ligand/receptor pair involved in osteoclast differentiation; ITGB3, encoding the β3 integrin involved in cytoskeletal organization; TCIRG1, encoding the a3 subunit of the v-ATPase; CA2, encoding carbonic anhydrase II; CLCN7 and OSTM1, encoding the chloride channel and a channel st...
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The lncRNA HIF1α-AS1 was retrieved as a top hit. Endogenous HIF1α-AS1 reduces the expression of numerous genes, including EPH Receptor A2 and Adrenomedullin through DNA:DNA:RNA triplex formation by acting as an adapter for the repressive human silencing hub complex (HUSH). Moreover, the ...
Among the cells proliferating in AS endothelial injury, one third are mononuclear macrophages, of which CD14+CD16+ monocytes have a strong pro-inflammatory effect[44]. Many cells, especially monocytes, macrophages, endothelial cells, and smooth muscle cells are susceptible to HCMV infection[26]; ...
The comparison of the structures in the absence and presence of NMN shows a compaction of the structure upon NMN binding (Figure S4K). However, a disulfide bond between residues near the NMN-binding site, found only in the ligand-free structure, may have stabilized a partially closed ...
Ivosidenib and Enasidenib are other chemical agents used to restrain the functionality of IDH1 and IDH2 mutant forms (in cancerous cells), respectively. The mutant forms cause a cascade of harmful intracellular changes such as enhanced 2-hydroxyglutarate production, an oncometabolite that inhibits th...
EPYC1 may be the molecular structure that enforces this spacing. The Pyrenoid Mixes Internally The Rubisco packing distribution we observed is consistent with either a liquid or an amorphous solid state. In order to discriminate between these states, a dynamic assay is necessary. The most direct ...
In this regard, it should be noted that prosaposin, which was previously identified as a ligand for GPR37 (refs 43,62), enhances OPC differentiation independently of the presence of GPR37 (Supplementary Fig. 10), suggesting that it is not the major ligand controlling the action of this ...
BIRC5 is an immune-related gene that inhibits apoptosis and promotes cell proliferation. It is highly expressed in most tumors and leads to poor prognosis in cancer patients. This study aimed to analyze the relationship between the expression level of BI