Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T(H)1) responses, which ...
Lung cellular senescence is independent of aging in a mouse model of COPD/emphysemaChemokinesChronic inflammationOxidative stress, chronic inflammation, and cellular senescence are intertwined in the pathogenesis of premature aging, which is considered to be an important contributory factor in driving ...
This chronic inflammatory response may induce parenchymal tissue destruction (resulting in emphysema), and disrupt normal repair and defense mechanisms (resulting in small airway fibrosis). These pathological changes lead to air trapping and progressive airflow limitation, and in turn to breathlessness ...
and/or "Have you taken any medication to treat bronchitis or emphysema or COPD in the last 2 weeks?" Those participants who answered negatively to these questions were considered not COPD patients. For each participant suffering COPD (case), we found in the database of the same survey a ...
His past medical history included diabetes, emphysema, and previous occupational exposure to asb... W Chou,J Mcardle - 《Pathology》 被引量: 1发表: 2013年 C3H female mice exposed to chronic cigarette smoke (CS) resemble the basic characteristics of chronic obstructive pulmonary disease (COPD) ...
COPD is the umbrella term that includes chronic bronchitis and emphysema. Both conditions reduce your ability to breathe and can result in a dry (or sometimes productive) cough. Food allergies. Sometimes certain foods can trigger coughing, and this may signal a food allergy. If you cough after...
Emphysema: Emphysema is a condition in which theairsacs in your lungs become damaged, causing them to collapse. It’s associated with smoking. COPD:Chronicobstructive pulmonary disease (COPD) is a lung disease that affects the airflow out of your lungs. It’s caused by smoking or exposure to...
airflow obstruction due to irregularities in the airways (bronchitis, bronchiolitis) or alveoli (emphysema) [1]. The pathogenesis of COPD involves complex interactions between genetic predispositions and environmental factors, significantly influencing susceptibility to the disease and its progression over an...
COPD is a chronic, debilitating and largely incurable form of progressive lung disease affecting more than 11 milllion Americans, according to the American Lung Association. A combination of bronchitis and emphysema, COPD is the third biggest killer in the United States. The new research "shows tha...
It is thought that PHT is due to vasoconstriction secondary to hypoxia caused by airway obstruction in COPD patients; however, loss of capillary bed with emphysema, inflammation and endothelial dysfunction may also play a role in the development of PHT. Epicardial adipose tissue (EAT) has a role...