Yang Y, Yang JJ, Tao H and Jin WS. YKL-40 and EGFR is a good biomarker for predicting nodal metastasis in anal carcinoma. Colorectal Dis 2014; 16: 69.Yang Y, Yang JJ, Tao H, Jin WS: YKL-40 and EGFR is a good biomarker for predicting nodal metastasis in anal carcinoma. Colorectal...
Moreover, the high molecular heterogeneity of GBM tumors, exemplified by unevenly distributed amplifications of EGFR and PDGFR, challenges the effectiveness of receptor tyrosine kinase inhibitors. Analysis of The Cancer Genome Atlas (TCGA) and single-cell RNA-seq further reveals substantial heterogeneity...
The current prognostic indica- tors for evaluating lung cancer include epidermal growth factor receptor (EGFR), K-ras gene mutation, TTF-1, Napsin A34–36; however, these indicators certain limitations in specificity and sensitivity. ERRα may be able to perform an auxiliary assessment in cases ...
The advent of high-throughput sequencing uncovered that our genome is pervasively transcribed into RNAs that are seemingly not translated into proteins. It was also found that non-coding RNA transcripts outnumber canonical protein-coding genes. This mindboggling discovery prompted a surge in non-codin...
This is a healthcare issue that everyone in the industry is aware of. While there is an ambition to tackle it, there are multiple barriers which make this a challenge. For many good reasons, the pharma industry is placing more immediate emphasis on challenges related to other areas, such as...
AOR: aortic diameter; AAO: aortic ascendens; CAD, coronary artery disease;BMI: body mass index; CK:creatine kinase; CK-MB: creatine kinase-isoenzyme; DBP:diastolic blood pressure; EF:ejection fraction; eGFR: estimatedglomerular filtration rate; HDL-C: high-density lipoprotein-cholesterol; hsCRP:...
Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma. Br J Cancer. 2003; 89 :1266–1269. doi: 10.1038/sj.bjc.6601241. [ Cross Ref ]allio JP,Hirvikoski P,Helin H. Membranous location of EGFR immunostaining is associated with good prognosis in ...
(A) AURKA phosphorylates RPS6KB1 is mutant K-Ras expressing cells. AURKA colocalizes and directly phosphorylates RPS6KB1 at T389 in K-Ras mutant gastrointestinal cancer cells leading to increased proliferation and survival. (B) AURKA activates EGFR signaling via SDCBP. AURKA stabilizes SDCBP by...
PDGFRβ in CAFs can interact with PDGF-BB expressed by cervical cancer cells and promote can- cer cell growth by upregulating the expression of hep- arin-binding epidermal growth factor (HB-EGF) and activating the EGFR signaling pathway [81]. In CRC, PDGFRβ-labeled CAFs increase the ...
1i, Supplementary Data 3), suggesting the involvement of post-transcriptional mechanisms downstream of KRASG12V. We used immunofluorescence microscopy, flow cytometry, and immunoblotting to validate these positive (EGFR, E-cadherin, N-cadherin, and CD44) and negative (ITGB1, EphA2, TLR4, TGFBR1...