Edoxaban transport via P-glycoprotein is a key factor for the drug's disposition. Drug Metab Dispos. 2014;42(4):520-8.Mikkaichi T, Yoshigae Y, Masumoto H, et al. Edoxaban transport via P-glyco- protein is a key factor for the drug's disposition. Drug Metab Dispos 2014; 42: 520-...
In the era of percutaneous coronary intervention with drug-eluting stents, dual anti-platelet therapy with the addition of clopidogrel (Plavix©, Bristol-Myers Squibb, New York, NY) became the mainstay of therapy. However, with the advent of newer oral antiplatelet medications, including ...
History of Liver Disease Does Not Impact Efficacy of Edoxaban; Patients with a-fib and history of liver disease more often had major bleeding but no increase in SSEE Dicerna added that the proposed parallel-group, placebo-controlled, Phase 1/2 study will evaluate the safety, tolerability, pharma...
The literature review sought 'dabigatran,' 'rivaroxaban,' 'edoxaban,' or 'apixaban,' and medicinal products that affected platelet function, including CYP3A4, CYP2C9, or P-gp activity. A significant 25% of 171 drugs with potential interaction with direct oral anticoagulants (DOACs) in atrial ...
Exclusion criteria were a known aspirin or clopidogrel intolerance (allergic reactions, gastrointestinal bleeding), a therapy with vitamin K antagonists (warfarin, phenprocoumon, acenocoumarol) or direct oral anticoagulants (dabigatran, rivaroxaban, apixaban and edoxaban), a treatment with ticlopidine, dipy...
(e.g. Rivaroxaban, Apixaban, or Edoxaban). In some embodiments, the patient may be on anticoagulant therapy. In some embodiments, the patient is on anticoagulant therapy selected from Warfarin, Heparin, low molecular weight Heparin, Heparin sodium, Heparin/Dextrose, Dalteparin, Hirudin, Lepirudin,...
Anticoagulants These medications reduce blood clotting and include heparin and warfarin, along with newer drugs like Pradaxa (dabigatran), Xarelto (rivaroxaban), Eliquis (apixaban) and Savaysa (edoxaban). (5) Learn More About Preventing Strokes Complications of Stroke A stroke may cause temporary or ...
355 2015 Edoxaban Cardiovascular LRiG FAD <£16,000 Higher 400 2016 Nivolumab Cancer BMJ Evidence FAD <£30,000* (with PAS) Higher ACD, appraisal consultation document; ERG, evidence review group; FAD, final appraisal determination; ICER, incremental cost-effectiveness ratio; LRiG, liverpool re...
While rivaroxaban, high-dose dabigatran, and high-dose edoxaban were associated with higher GIB rates than warfarin, GIB rates were similar between warfarinusers and both apixaban and low-dose dabigatranusers. Additionally, previous observational studies have yielded conflicting reports on whether GIB ...
While rivaroxaban, high-dose dabigatran, and high-dose edoxaban were associated with higher GIB rates than warfarin, GIB rates were similar between warfarin users and both apixaban and low-dose dabigatran users. Additionally, previous observational studies have yielded conflicting reports on whether GIB...