DNA synthesis, sequencing, and purification processes are still expensive and resource-intensive. Synthesizing the required DNA sequences and reading the data (through sequencing) still incur significant costs because we need specialized equipment and highly controlled lab environments. Programming DNA-based...
The growing field of RNA sequencing (RNA-Seq) seeks to elucidate the many roles of RNA in the modulation of cellular and biological processes, not only as an intermediate molecule but in its other functions. RNA-Seq provides both qualitative and quantitative information about the different RNA sp...
The Joint Genome Institute, a Department of Energy consortium located in Walnut Creek, CA, has emerged as a leader in mining the seemingly endless deposits of genetic data coming from sequencing efforts around the world. Researcher Natalia Ivanova was parsing this data when she noticed something st...
A DNA data storage facility in the future might look vastly different from current data centers. Instead of rows of servers and hard drives, a DNA data storage facility might resemble a high-tech laboratory. There would be automated systems for DNA synthesis, sequencing, and storage, and specia...
Macquarie Capital analyst Jon Groberg expects a resetting or price expectations going forward in the sequencing market and sees the product launches as a signal of the end of expensive instruments. Chart compares the technical specifications of the as-yet released DNA sequencing machines Life Proton ...
Some workloads, such as DNA sequencing, are simply too immense for any single computer to process. HPC or supercomputing environments address these large and complex challenges with individual nodes (computers) working together in a cluster (connected group) to perform massive amounts of computing in...
DNA for whole genome sequencing was isolated from young leaves by grinding in 100 mM TRIS–Cl, 20 mM EDTA, 1.4 M NaCl, 2% (w/v) CTAB, 1% each polyvinylpyrrolidone and sodium metabisulfite pH 8.0. Samples were treated with 70 µg/ml RNAaseA (ThermoFisher, Waltham, MA), ...
This remit should be discriminated clearly from data generation for more exploratory projects, in which the aim is to understand biological relationships through the profiling of biological systems using biochemical or high-throughput experiments such as DNA sequencing [17] or proteomics technologies (for...
Advances in DNA sequencing technology and computational analysis have further decreased the amount of time and labor required to produce genetically manipulated mice. New developments in mouse genetics are constantly being published, and as these technologies are fully validated and optimized, the ...
Next-generation sequencing (NGS): This technique determines the sequence of DNA, which can be used to identify genetic disorders caused by changes in the DNA sequence. What is preimplantation genetic diagnosis (PGD)? Preimplantation genetic diagnosis (PGD) is a type of PGT that tests for a know...