Due to the increased diffusion distance, protons accumulate in the TME and pHe decreases. MCT, monocarboxylate transporter. b Left, in non-tumour cells, the proton concentration within the cells is slightly higher than outside of the cells. Right, in cancer cells, the activity of acid-...
In contrast to active transport, facilitated diffusion is a spontaneous passive process, in which the molecules move down a concentration gradient across a biological compartment by specific carrier proteins. Thus, we hypothesized that the water-soluble nsLTPs localized in the cell wall could ...
An overall mechanism for the serial formation of oxygen clusters (Oi)n at T≤ 500 °C has been proposed and these defects might be directly related to TDN centres. A requirement is rapid diffusion of O2 dimers and further evidence for this process should be sought to confirm or reject the...
Cells were aligned along a pseudotime trajectory using a diffusion map61, which was computed with the ‘diffmap’ function from the scanpy package on the first 20 principal components. We performed all differential gene expression analyses with Wilcoxon’s rank sum test, with an FDR threshold of...
Estimation of the hydraulic diffusion time We calculated the hydraulic diffusion time across the gouge layer during the seismic slip velocity experiments as thy = d2/αhy, where d is the gouge layer half-thickness (m) and αhy is the hydraulic diffusivity (m2/s). Hydraulic diffusivity is...
First, given ECT performance is typically differentiated more by response latency rather than accuracy, performance indices were derived using drift diffusion modelling. In total, standardized drift rates were derived for 12 indicators, 3 speed tasks (change-detection, stimulus comparison, substitution) ...
Among obtained compounds the best antibacterial activity in the agar disc diffusion test showed derivative 21 with bromine group into the basic coumarin structure. The zones of growth inhibition for E. coli and S. aureus had a diameter of 20 mm and 24 mm respectively at the compound ...
however, they are less conserved in comparison with themraY,murF,alr,ddl, andmurGgenes (Fig.6A & B). However, in the Kirby-Bauer disc diffusion method the IS-10506 strain showed a halo of 11 cm (unpublished data), and in contrast to manyL. plantarumstrains shows intermediate resistance ...
The latter case would suggest that some toxic damage is not efficiently repairable but can instead be ‘automatically’ segregated by a passive, diffusion-based mechanism. More evidence supporting the predictions of UnicellAge There is more empirical backing for the predictions of UnicellAge than the...
Taken together, our data strongly suggest that RP3V kisspeptin neurons mediate sexual behavior and that hypothalamic NO signaling could be an essential mechanism downstream of kisspeptin neurons in governing sexual behavior. The discovery that a neuropeptide that governs ovulation is also able to elicit...