Is cytotoxic chemotherapy for lymphoma currently feasible for patients in Malawi? A debate.doi:10.4314/MMJ.V20I4.10979Emma CrutchlowYohannie MlombeTom LathamMedical Association of Malawi
Cytotoxic lymphocytes such as Natural Killer (NK) cells can result in leukemias and lymphomas with aggressive clinical course. The cytoplasmic granules of NK cells contain molecules that cause apoptosis of their target cells. In this study, we examined changes of the cytotoxic granules of the Natura...
Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy Cancer-associated genetic alterations induce expression of tumour antigens that can activate CD8(+) cytotoxic T cells (CTLs), but the microenvironment of established tumours promotes immune tolerance through poorly understood mecha...
Chemotherapy is an aggressive approach performed by the injection of anti-cancer (cytotoxic) drugs to kill growing cells in the body. It has been shown that chemotherapeutic drugs are persistent in the bloodstream, so can affect the organs, tissues, and immune cells. Although chemotherapy kills ra...
The prevalence of CHIP is higher in patients with cancer who have been exposed to cytotoxic chemotherapy or radiation and is associated with worse clinical outcomes, including a higher risk of progression to a TMN18. Multiple reports have also demonstrated that CHIP is detectable in up to 30% ...
The cytotoxic effects of brevilin A on NCM460, CRC cells and HSCs were evaluated by using the MTT assay. Cells were seeded in a 96-well plate, and then treated with various concentrations of brevilin A. After 24 h, 20 μL of MTT solution (5 mg/mL) was added and incubated for anothe...
The patient did not respond to prior targeted therapies or immunotherapies but experienced a dramatic objective radiological and clinical response to subsequent dacarbazine-based chemotherapy. In the era of targeted therapies and immunotherapies for metastatic melanoma, cytotoxic chemotherapies may still ...
1). The gap is closely associated with the identification of the rare cell type Cn, as it can be approximated by the distance between any given cell m in Cn and its nearest neighbour from Cneighbour (the first box in Fig. 1), since the gap is large relative to the minor cluster Cn...
Cytotoxic T lymphocyte (CTL)-based cancer immunotherapies have shown great promise for inducing clinical regressions by targeting tumor-associated antigens (TAA). To expand the TAA landscape of pancreatic ductal adenocarcinoma (PDAC), we performed tandem mass spectrometry analysis of HLA class I-bound...
TAM-RTK plays a major rate-limiting role in innate immune cell function, conferring APC tolerance and ultimately inhibiting antitumour cytotoxic T cells. TAM-driven tumour-promoting pathways in M2 polarization, including the inhibition of DC activation and the suppression of chemokines that mediate T...