Human Mycobacterium tuberculosis-reactive CD4+ T-cell clones: heterogeneity in antigen recognition, cytokine production, and cytotoxicity for mononuclear p... CD4+ T cells regulate the protective immune response which follows exposure to Mycobacterium tuberculosis by activating macrophages through the cytokin...
Extended survival was also associated with an increased per cell phosphorylation of STAT-5 in cytotoxic T-cells following IL-2 stimulation when the median post/pre pSTAT-5 ratio was used to dichotomize the patients (p???=???0.0015, log-rank survival; hazard ratio???=???0.1834, p???=?
Augmentation of these surface markers was concomitant with diminution of IFN-γ, a cytokine critical for cell-mediated responses to tumors. These collective changes are akin to dNK cells that are not cytotoxic and instead support the implant. Importantly, all alterations were restored if NK cells ...
These results strongly suggest that DC vaccination is specifically followed by a heightened response to a typical gamma chain cytokine associated with lymphocyte survival in cytotoxic T cells from glioblastoma patients. Figure 2 Dose-dependent changes in pSTAT-5 by CD3 + CD8 + T cells in response...
The HESN group did trend toward lower expression of HLA- DR on CD8 + T cells (relative proportion P = 0.07, median fluorescence intensity P = 0.1). Correlation between chemokine/cytokine and antiprotease expression at the FGT One of the roles of chemokine/cytokine expression at the FGT is ...
- 《Cytokine》 被引量: 72发表: 2012年 Association between the CTLA-4 +49 A/G polymorphism and susceptibility to rheumatoid arthritis: a meta-analysis The aim of this study was to explore whether the cytotoxic T lymphocyte antigen-4 (CTLA-4) +49 A/G polymorphism confers susceptibility to ...
Culture supernatants of psoriatic lesion-infiltrating T cells strongly induced all four CEACAM1 isoform transcripts, which was mainly dependent on the presence of IFN-γ, as shown by the depletion of the latter cytokine using a specific mAb. As is shown in Figure 6b, the primer combinations ...
The resulting T cell-T cell immune synapse leads to (1) Activation of effector CTLs, as determined by proliferation, cytokine secretion and degranulation; (2) Fratricide (killing) of CD8+T-APCs by the activated CTLs. Thus, trogocytosis enables cross-reactivity among CD8+ T cells with inter...
In order to evaluate quantitatively the type 1 cytokine bias, we compared the frequency of type 2 interleukin-4 producing versus type 1 interferon-γ producing T cells in our assay and found a shift towards type 1 producing cells. This shift reveals a type 1 differentiation bias in both...
Frisan T, Dalianis T, Ljungman P, Ringden O, Winiarski J, Ernberg I & Masucci MG (2000) Epstein-Barr virus (EBV) load in bone marrow transplant recipients at risk to develop posttransplant lymphoproliferative disease: prophylactic infusion of EBV-specific cytotoxic T cells. Blood 95: 80...