Cyproheptadine improves serotonin syndrome through 5-HT2 antagonism, but it can potentially worsen anticholinergic delirium because of its anticholinergic effect.2 Benzodiazepines may be beneficial for treating agitation, seizures, and stiffness. Antipsychotics with 5-HT2A antagonism, such as olanzapine, ...