Like the peptide transporters, =-=(4, 5, 23)-=-, we propose that the molecular chaperone calnexin is an integral component of the class I antigen ... Spies,DeMars - 《Nature》 被引量: 688发表: 1991年 Novel endoplasmic reticulum-localized protein, remedies containing the same for diseases...
n=Molecular massEmpirical formula mass A compound may have same empirical and molecular formulae Both these formulae are calculated by using percentage composition of constituent elements. A compound of Na, C and O contains 0.0887 mol Na, 0.132 mol O and2.65×1022atoms of carbon . the empirical...
KRAS proteins had long been considered “undruggable” until the identification of covalent drugs targeting KRAS(G12C)2,3. The drug sotorasib (AMG510, 1) was recently approved for treatment of patients with the KRAS(G12C) mutation, and six additional drugs targeting this same mutant are ...
. Furthermore the STEC strain that is recovered undergoes molecular subtyping (DNA fingerprinting) to group cases together – cases that occur around the same time and have the same DNA fingerprint of O157, for example, are more likely to have acquired their infection from a common source and ...
Thomas A, Jourand D, Bret C, Amara P, Field MJ (1999) Is there a covalent intermediate in the viral neuraminidase reaction? A hybrid potential free-energy study. J Am Chem Soc 121: 9693-9702Is there a covalent intermediate in the viral neuraminidase reaction? A hybrid potential free-...
A) What are intermolecular forces and how do they compare to intra-molecular forces such as ionic or covalent bonding? B) What impact do intermolecular forces have on the melting point and the boiling point of a substance? The predominant intermolecular force in AsH_3 is: A)...
Why Is There a Lack of Consensus on Molecular Subgroups of Glioblastoma? Understanding the Nature of Biological and Statistical Variability in Glioblastoma... J. Weil (2011): "Why is there a lack of consensus on molecular subgroups of glioblastoma? understanding the nature of biological and ...
The 9-1-1 DNA checkpoint clamp is loaded onto 5′-recessed DNA to activate the DNA damage checkpoint that arrests the cell cycle. The 9-1-1 clamp is a heterotrimeric ring that is loaded in Saccharomyces cerevisiae by Rad24-RFC (hRAD17-RFC), an alternate
Hydrocarbons and Molecular FormulaeA hydrocarbon is an organic compound that contains only carbon atoms and hydrogen atoms. The carbon atoms are linked through covalent bonds in a long chain to each other, and the hydrogen atoms are attached to the carbon a...
At the same time, almost all targeted anticancer drugs will encounter resistance after a period of clinical use. TPD technology can solve the problem of drug resistance caused by target pocket mutations, bringing hope to patients. Among them, PROTAC and molecular glue are currently the two most...