isoxazolidine, oxime, addition reactions, regioselectivity, Lewis acidsThe 1,4-addition of N, O-bis(trimethylsilyl)hydroxylamine to alkylidene acetoacetates afforded in one step 3,4,5-trisubstituted isoxazolidines. An investigation on the effect of the Lewis acid catalysis on the regios...
Aluminum chloride is used extensively as Lewis acid catalyst in a variety of industrial processes, including Friedel−Crafts and Cl/F exchange reactions. There is a common misconception that pure AlCl3 is itself a Lewis acid. In the current study, we use experimental and computational methods to...
While we have recently disclosed that the use of Lewis acid (LA) cocatalysts significantly promotes the carbocyanation reaction of alkynes to allow the addition of acetonitrile, the attempted addition of propionitrile resulted in a low yield of the corresponding ethylcyanation product due to β-...
017 bp) between ecotypes. Although mammalian Hox gene sequences are highly conserved49, we found thatHoxd13had a 3 bp insertion at amino acid position 109 in the disordered N-terminal region of the protein50. The mutation was fixed between our laboratory colonies of forest and prairie...
Consistent with our hypothesis, we found differing effects of α-synMon female LDT neurons when compared to male. In females, α-synMinduced a decrease in membrane excitability and heightened reductions in intracellular calcium, which were reliant on functional inhibitory acid transmission, as well as...
Together, these results indicate that copper bioavailability is a KRAS-selective vulnerability that could be exploited for the treatment of KRAS-mutated neoplasms.Similar content being viewed by others The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer ...
This is despite the fact that there is a 69 % amino acid identity between FPR1 and FPR2 [4]. It should be mentioned that AZ2158 has been shown to dose-dependently inhibit FPR1 dependent migration of cells from a cancer cell line (U87-MG) but for full inhibition very high ...
This also confirms that the funnel-shaped structure formed by the N-terminal α1 helix is sufficient to penetrate the lipid bilayer, which is consistent with previous finding that a 20 amino acid antimicrobial peptide of alamethicin can form an ion channel (Hall et al., 1984). The ZAR1 ...
Following dewaxing and rehydration, antigen retrieval was performed with 10 mM citric acid (pH 6.0). Dissociated islet cells were fixed in 4% PFA for 15 min and centrifuged onto glass slides. Pancreatic sections and dissociated islets were then blocked using 5% donkey serum for 1 h at...
Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase Haley A. Vecchiarelli, Maria Morena, Catherine M. Keenan, Vincent Chiang, Kaitlyn Tan, Min Qiao, Kira Leitl, Alessia Santori, Quentin J. Pittman, ...