Peak heights are proportional to the amount of nucleotide present in the sequenced DNA. (top panel) Results from healthy control showing equal heights of the 1849G and the following T peak. The last peak is of double height, reflecting 2 adjacent G nucleotides. (middle panel) Ph–CML, with...
Pandrala et al., designed a novel inhibitor for CML with enhanced cardiac safety and low toxicity [1]. In acute myeloid leukemia (AML), efforts led to the discovery of a class of compounds with anti-mitotic activity based on the inhibition of tubulin polymerization [2]. These anti-tubulin...
Abbreviations: MDS: myelodysplastic syndrome; CMML: chronic myelomonocytic leukemia; CML: chronic myeloid leukemia; CLL: chronic lymphocytic leukemia; MF: myelofibrosis; PV: polycytemia vera; ITD: internal tandem repeat. We estimated the number of viable cells after the initial five weeks of ...
In addition, we studied possible phenotypic alterations accompanying the occurrence of JAK2 V617F in these disorders. Other than chronic myeloid leukemia (CML), which is characterized by the presence of the Philadelphia chromosome or its molecular equivalent (ie, the BCR/ABL fusion oncogene, ...
Molecular processes required for leukemogenesis in vivo may or may not be the same as that for cellular transformation in vitro. We have previously shown that oncogenic NRAS effectively induces a CMML or AML-like disease in a mouse bone marrow transduction and transplantation model.31 Here, we ...