Based on its high affinity for cloned dopamine receptors, clozapine was proposed to work as a dopamine Dantagonist in schizophrenia. This, coupled with the reports of elevated dopamine Dreceptor density in post-mortem schizophrenic brains, propelled much effort to seek a new potent dopamine Ddrug....
Determinants of work outcome in neuroleptic-resistant schizophrenia and schizoaffective disorder: cognitive impairment and clozapine treatment. Psychiatry Res. 178, 57–62 (2010). Article CAS PubMed Google Scholar Widiyawati, W., Yusuf, A., Devy, S. R. & Widayanti, D. M. Family support ...
Mice were acutely injected 30 mins before the testing session with clozapine N-oxide (CNO, i.p. 1 mg/kg) using 0.9% NaCl as a vehicle. Novelty-suppressed feeding test (NSF) was done as described before [4] using a plastic box (50 cm × 80 cm × 20 cm) as ...
We found that baseline Anti-14-3-3z monoclonal antibodies were generated in a female BALB/c hyperactivity of KO mice is rescued by the antipsychotic drug clozapine and that KO mice are hypersensitive to the DA releaser amphetamine. In strong support of DA underpinning some of the schizophrenia-...
Clozapine is an atypical neuroleptic drug characterised by a striking lack of extrapyramidal side effects. Although these features would seem to make clozapin an unlikely agent for the induction of neuroleptic malignant syndrome (NMS), several putative clozapin-related cases of NMS have recently been...
Is Clozapine a course of NMS, or a neuroleptic drug of choice for patients with a history of NMS, or both?Weller, MKornhuber, JFortschritte Der Neurologie Psychiatrie
Schulte P. What is an adequate trial with clozapine?: therapeutic drug monitoring and time to response in treatment-refractory schizophrenia. Clin Pharmacokinet 2003;42(7):607-18.Schulte P. What is an adequate trial with clozapine? therapeutic drug monitoring and time to response in treatment-...
Is clozapine-induced leukocytosis due to the drug?Blood-dyscrasias, drug-inducedClozapine, adverse reactionsReactions Weekly -doi:10.2165/00128415-199304680-00011&NA;Springer International PublishingReactions Weekly
Shadach E, Weiner I, Feldon J (1999) Clozapine-induced poten- tiation of latent inhibition is due to its action in the conditioning stage: implications for the mechanism of action of antipsy- chotic drugs. Int J Neuropsychopharmacol 2:283-291...
The article discusses a study, which conducted an electronic search of different databases and a manual search of articles between 1960 and 2011, which concluded an upper threshold related to clinical response suggests a ''ceiling effect'' in the range of 600-838 ng/ml for Clozapine....