Iron is essential for living cells. Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been assumed. Here, we demonstrate that CD71 utiliz
we asked whether chimeric LDLRAD3, where the native D1 domain is replaced by the CR5 domain of LDLR, can serve as a GETV receptor. Similarly, we investigated if the reciprocal swap would enable VEEV to use chimeric LDLR as a receptor. It was found that the chimeric receptors were expres...
Clathrin adaptorsEndocytosisHypercholesterolemiaCholesterol plays a vital role in multiple physiological processes. Cellular uptake of cholesterol is mediated primarily through endocytosis of low-density lipoprotein (LDL) receptor. New modifiers of this process remain to be characterized. Particularly, the role...
Receptor endocytosis is an important mechanism for regulating the synaptic efficacy of neurotransmitters. There is strong evidence that GABA(A) receptor endocytosis is clathrin-dependent; however, this process is not well understood. Here we demonstrate that in HEK 293 cells, endocytosis of GABA(A) ...
Jisaka, et al., The tyrosine-sorting motif of the vacuolar sorting receptor VSR4 from Arabidopsis thaliana, which is involved in the interaction between VSR4 and AP1M2, 1-adaptin type 2 of clathrin adaptor complex 1 subunits, participates in the post-Golgi sorting of VS, Biosci. ...
Instead, they indicate that CG membranes are maintained together as "microdomains" after full-fusion exocytosis; subsequently, they are recaptured in a clathrin-dependent manner without intermixing with the plasma membrane. Further insight into the role of lipids as regulators of exo- endocytosis and ...
A recent study demonstrated that epidermal growth factor and transforming growth factor-α internalize after binding to the epidermal growth factor receptor initially via clathrin-coated vesicles, but at 30 minutes of chase are found on the outer membrane of MVBs,63 analogous to the location of A...
展开 关键词: CORTICAL ACTIN CYTOSKELETON MAP KINASE PATHWAY A-FACTOR RECEPTOR SACCHAROMYCES-CEREVISIAE INTEGRITY PATHWAY PLASMA-MEMBRANE SECRETORY PATH PROTEIN UBIQUITIN CLATHRIN DOI: 10.1017/S0021859601008541 被引量: 100 年份: 2007 收藏 引用 批量引用 报错 分享 全部...
The sequence of amino acids surrounding Y191 resemble known substrate phosphorylation sites for some nonreceptor cytoplasmic tyrosine kinases, as well as tyrosine-based recognition signals associated with clathrin vesicle-mediated cndocytosis. View Full Article (HTML) Get PDF (162K) More content like ...
There are several endocytic pathways, which are either dependent on or independent of clathrin. This study focuses on a poorly characterized mechanism - clathrin- and caveolae-independent endocytosis - used by the interleukin-2 receptor beta (IL-2R beta). We address the question of its regulation...